26.2 MEDSCI 320 - Block 1 Drugs List

amitriptyline [class]

Tricyclic Antidepressant (TCA)

escitalopram [class]

Selective Serotonin Reuptake Inhibitor (SSRI)

venlafaxine [class]

Serotonin and Noradrenaline Reuptake Inhibitor (SNRI)

buproprion [class]

NA and DA reuptake inhibitor

buspirone [class]

Anxiolytic (5HT agonistic)

lithium [class]

Mood Stabiliser

mirtazapine[class]

Noradrenaline and Selective Serotonin Antidepressant (NaSSA)

phenelzine [class]

MAO inhibitor

moclobemide [class]

MAO inhibitor (selective)

trazodone [class]

5-HT receptor antagonist with 5-HT reuptake inhibition (SARI)

diazepam [class]

Anxiolytic (allosteric modulator)

donepezil (Aricept)[class]

Cholinesterase Inhibitor

memantine [class]

NMDA antagonist

L dopa (levodopa) [class]

Dopamine precursor

bromocriptine [class]

DA receptor agonist

benztropine [class]

Anticholinergic

entacapone [class]

COMT inhibitor

amantadine [class]

Anti-viral agent

selegiline [class]

MAO-B inhibitor (selective)

amitriptyline [MoA]

Blocks reuptake of 5HT and NA, antagonist at histamine and Ach receptors

escitalopram [MoA]

Selectively (most selective) inhibits reuptake of 5HT

venlafaxine [MoA]

Inhibits reuptake of 5HT and NA

buproprion [MoA]

Inhibits reuptake of DA and NA

buspirone [MoA]

Agonist at 5HT1a (full at presynaptic, partial at post-synaptic), decreases 5HT, increases NA and DA

lithium [MoA]

Regulation of NMDA receptors, inhibit GPCRs, inhibit IP3 production

mirtazapine [MoA]

Antagonises alpha-2 autoreceptors (adrenergic) and heteroreceptors (5HT); antagonises 5HT2A and 5HT3 postsynaptic receptors

phenelzine [MoA]

Non-selective and irreversible MAO inhibitor

moclobemide [MoA]

Reversible inhibitor of MAO-A

trazodone [MoA]

Antagonizes 5HT 2A and 2C receptors; inhibits 5HT, NA and DA reuptake

diazepam [MoA]

Positive allosteric modulator of GABA A receptor

donepezil (Aricept) [MoA]

Inhibits the breakdown of acetylcholine, increasing levels within the CNS

memantine [MoA]

Decreases excessive, possibly pathological, glutamatergic transmission

L dopa (levodopa) [MoA]

Precursor for dopamine synthesis, promoting dopamine levels

bromocriptine [MoA]

Dopamine agonist at D1 and D2 receptors

benztropine [MoA]

Competitive mAch antagonist in striatum, restoring usual cholinergic activity

entacapone [MoA]

COMT inhibitor, reduces the breakdown of dopamine

amantadine [MoA]

Weak non-competitive antagonist of NMDA receptor, increases DA release, inhibition of DA reuptake

selegiline [MoA]

MAO-B inhibitor, reduces the breakdown of dopamine