Studied by 89 PeopleFatty acids are carboxylic acids with hydrocarbon chains how many carbons long? Most commonly, they are found with chains about how many carbons long?
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Fatty acids are carboxylic acids with hydrocarbon chains how many carbons long? Most commonly, they are found with chains about how many carbons long?
Fatty acids are carboxylic acid hydrocarbon chains 4 to 36 carbons long. Commonly, they are found 12-24 carbons long.
Describe the carbon-skeleton nomenclature system for labelling fatty acids. For example, what does 18:2(Δ⁹,¹²) mean?
The left side of the colon denotes the number of carbons in the chain. The right side of the colon denotes the number of double bonds in the chain.
The Δ and following numbers denote the locations of the double bonds.
In most monounsaturated fatty acids, the double bond is found at which carbon?
Carbon 9. To be more clear, it is found between C9-C10.
But it is labeled as A:1(Δ⁹)
Double bonds of polyunsaturated fats are typically separated by what?
A methylene group.
Nearly all unsaturated fatty acids have their double bonds in the ____ (cis/trans) configuration.
cis
What kind of polyunsaturated fats are especially important regarding human nutrition? What kind of nomenclature is used to refer to these fats?
Fatty acids with a double bond between the C3-C4 FROM THE END of the chain. These are known as omega-3 fatty acids.
Physical properties of fatty acids are largely determined by what?
Length and degree of unsaturation of the hydrocarbon chain.
Describe the effect of increasing/decreasing length and degree of unsaturation on the solubility of a fatty acid.
As nonpolar hydrophobic chain length increases, solubility decreases. As double bonds increase, solubility increases.
Describe the effect of increasing/decreasing length and degree of unsaturation on the melting point of a fatty acid.
Saturated fatty acids have less kinks, allowing it to easily remain solid at higher temperatures. This means more unsaturation lowers the melting point.
As the chain length increases, melting point also increases.
Describe how double bonds affect the melting point of different fatty acids?
Melting point refers to how easy it is for fatty acids to "pack together," so if there are less "kinks" in the chain, it packs together more easily into a solid form.
What are the molecular components of a triacylglycerol? What bond connects them?
Three fatty acids all ester-linked to a glycerol.
Are triacylglycerols polar or nonpolar? Why?
Nonpolar. While glycerol has polar hydroxyls and the fatty acids have polar carboxyls, they are joined in ester linkages, rendering the molecule as a whole nonpolar and insoluble in water.
What is an adipocyte? What is an enzymatic component within adipocytes? What does that enzyme do?
A cell that specializes in storing fats. They usually contain LIPASES. Lipases catalyze hydrolysis of stored triacylglycerols.
What is the main function of triacylglycerols? What is a secondary function found in some animals?
Triacylglycerols are primarily for usage as stored fuel. In some animals, they are used as cellular insulation. (E.g. "blubber" in seals, walruses, penguins, etc.)
Name 2 advantages of using triacylglycerols as stored fuel instead of polysaccharides like glycogen or starch.
Fatty acid carbon atoms are more reduced than those in sugars, so upon oxidation, they release more energy gram for gram compared to sugars.
Triacylglycerols are hydrophobic. Because they do not dissolve in water, the cell does not have to push the "water-weight" associated with transporting soluble energy such as sugars.
In short: it's easier, faster, and releases more energy.
What occurs during hydrogenation of a fatty acid? Why is this done to commercially marketed fats?
Hydrogenation involves the conversion of cis-double-bonds to single bonds. This is done commercially to prolong the shelf life of fats. Single bonds are much less susceptible to oxidation.
Describe biological waxes in terms of their molecular components.
Long chain saturated and unsaturated fatty acids ester linked to long chain alcohols.
What are some functions of biological waxes?
Waterproofing, insulation, structure, lubrication.
What is the key feature of all membrane lipids?
They are amphipathic.
What are the four general types of membrane lipids?
Phospholipids, glycolipids, archaeal tetraether lipids, and sterols.
Describe the molecular components/bonds of: Glycerophospholipids (also called phosphoglycerides)
Its backbone is glycerol; it contains 2 fatty acids, ester linked at C1, C2 1 phosphate head group + alcohol at C3 via phosphodiester bond
In a glycerophospholipids/phosphoglycerides, the phosphate group bears a ____ (negative/positive/neutral) charge at neutral pH.
Negative.
What is a plasmalogen?
A type of glycerophospholipid with an ether-linked chain and double bond between C1 and C2.
Describe the molecular components/bonds of: Glycolipids (also called sulfolipids)
Its backbone is glycerol; it contains 2 fatty acids, ester linked at C1, C2 1 mono/di-saccharide head group at C3 via glycosidic linkage
What is the most abundant membrane lipid in the biosphere?
Galactolipids; they are a type of glycolipid abundant in thylakoid membranes. They make up 70%-80% of the total membrane lipid content of vascular plants.
Describe the linkages within membrane lipids within some archaea living within ecological extremes. In other words, how are their membranes so resistant to high temperature or low pH?
They have their fatty acid chains linked via ETHER bond instead of ester bond; ether groups are much more resilient against hydrolysis at these ecological extremes.
Describe the molecular components/bonds of: Sphingolipids
Sphingolipids are a subtype of both glycerophospholipids AND glycolipids. Its backbone is sphingosine; it contains 1 long nonpolar chain (part of sphingosine) 1 (nonpolar) fatty acid chain 1 polar head group; Head group is either a phosphate or sugar. (attached via phosphodiester bond or glycosidic linkage)
Describe what makes a sphingolipid a ceramide.
When the fatty acid is attached to the sphingosine's C2 via amide linkage.
What are the functions of ceramides?
Regulation of protein kinases, cell division, differentiation, migration, and apoptosis.
What are the three subclasses of sphingolipids? What do all of them have in common, and where do they differ?
Sphingomyelins, glycosphingolipids, and gangliosides. Common: All derivatives of ceramides. Differ: Head groups
Describe sphingomyelins. Out of the four general types of membrane lipids, which does this fall under?
Sphingomyelins are sphingolipids, specifically ceramides, whose head groups are phosphocholine or phosphoethanolamine.
Sphingomyelins are phospholipids.
Describe glycosphingolipids Out of the four general types of membrane lipids, which does this fall under?
Glycosphingolipids are sphingolipids whose head groups are one or more saccharides connected directly to the C1-OH of the ceramide.
Glycosphingolipids are glycolipids because their head groups are sugars
What are the two subtypes of glycosphingolipids called? What differentiates them?
Cerebrosides: One sugar head group. Globosides: Two or more sugar head groups.
Describe gangliosides. Out of the four general types of membrane lipids, which does this fall under?
Gangliosides are sphingolipids whose head groups are comprised of oligosaccharides with N-acetylneuraminic acid (Neu5Ac) at the ends.
What distinguishes gangliosides from globosides?
Gangliosides, due to their Neu5Ac end groups, are negatively charged at neutral pH. Globosides are uncharged at neutral pH.
What enzymes within the lysosome degrade glycerophospholipids?
Phospholipase A removes one fatty acid, degrading the glycerophospholipid into what is called a lysophospholipid.
Then, a lysophospolipase cleaves the remaining fatty acid
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Describe the molecular components/bonds of: Sterols
Sterols are characterized by the steroid nucleus, made up of four fused rings.
All sterols in eukaryotes are made from isoprene subunits. Side groups are as follow: Fatty acid chains attached at C17 Polar head group attached at C3
What are other functions of lipids, aside from structure and storage?
Signaling, acting as cofactors, becoming pigments.
What is PIP2? What is its function?
Phosphatidylinositol 4,5 bisphosphate Its function is to serve as a reservoir of signaling molecules. Upon cleavage by phospholipase C, it yields signaling molecules.
What signal molecules does PIP2 release upon hydrolysis?
inositol 1,4,5 triphosphate (water soluble, travels) diacylglycerol (remains membrane-associated)
What is PIP3? What is its function?
Phosphatidylinositol 3,4,5-triphosphate It serves as the nucleation point (beginning molecule) for supramolecular complexes of signaling proteins to form.
What is an eicosanoid? What are their general functions in the body?
Paracrine hormones; meaning a hormone that only acts on cells adjacent to the site of its synthesis. They are involved in reproductive function, inflammation, fever, etc.
What molecules are eicosanoids derived from? (hint: eikosi, Greek for "20")
Arachidonic acid, 20:4(Δ5,8,11,14) Eicosapentaenoic acid, 20:5(Δ5,8,11,14,17)
What are the four major classes of eicosanoids?
prostaglandins, thromboxanes, leukotrienes, and lipoxins
Describe the characteristic molecular components of prostaglandins. What are their functions?
Prostaglandins are characterized by their 5-membered ring.
Their functions include:uterus contraction during menstruation and labor, blood flow to specific organs, the wake-sleep cycle, regulating responsiveness of certain tissues to hormones, elevation of body temperature causation of inflammation and pain.
Describe the characteristic molecular components of thromboxanes. What are their functions? (hint: what are they produced by?)
Thromboxanes are characterized by their 6-membered ring containing an ether. Produced by thrombocytes (blood platelets)
Their functions include: formation of blood clots and reduction of blood flow to the site of a clot.
Describe the characteristic molecular components of leukotrienes. What are their functions?
Leukotrienes are characterized by their linear chain with 3 conjugated double bonds.
Their functions include: contraction of smooth muscle (leukotrienes are the cause for asthmatic attacks)
Describe the characteristic molecular components of lipoxins. What are their functions?
