non-hodgkin's lymphoma

how many different types of non-hodgkins lymphomas are there?

over 60

how can you classify NHLs?

70% - B-cell origin

30% - T-cell origin

what are 3 of the main types of NHLs?

- Burkitt lymphoma

- MALT lymphoma

- diffuse large B cell lymphoma

what is Burkitt's lymphoma associated with?

- Epstein-Barr virus

- malaria

- HIV

what is MALT lymphoma associated with?

H. pylori infection

what is diffuse large B cell lymphoma characterised by?

rapidly growing painless mass in pts over 65

what are the risk factors associated with NHL? (6)

- HIV

- Epstein-Barr virus

- H.pylori

- Hep B or C infection

- exposure to pesticides or trichloroethylene used in several industrial processes

- family history

what are the clinical features of NHL? (7)

- lymphadenopathy

- fever

- night sweats

- weight loss

- pruritus

- splenomegaly

- hepatomegaly

what are the features of B-cell lymphomas? (2)

- painless

- less aggressive

what are examples of B-cell lymphomas? (3)

- follicular lymphoma

- MALT lymphoma

- small lymphocytic lymphoma/chronic lymphocytic leukaemia

what are the features of T-cell lymphomas? (2)

- usually have skin infiltration

- tend to be more aggressive

what are some types of T-cell lymphomas? (5)

- cutaneous T-cell lymphoma

- T-cell lymphoblastic lymphoma

- adult T-cell lymphoma

- anaplastic lymphoma

- T-cell lymphoblastic leukaemia

what are the two stages of cutaneous T-cell lymphoma?

- mycosis fungiodes (nothing to do with fungi)

- sezary syndrome

what does mycosis fungiodes present as?

skin lesions, plaque tumours, ezcema reaction

what is sezary syndome?

late stage mycosis fungiodes with lymphadenopathy