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* Foreign body in the ear (especially in children) may present with purulent ear discharge and pain.
* Impacted ear wax — may cause pain and hearing loss.
* Skin conditions
* Referred pain — may originate from the teeth, sphenoidal sinus, neck, or throat.
* Cholesteatoma — causes persistent or recurrent ear discharge and fullness, but is typically painless. There may be a perforated tympanic membrane, retraction pocket in the tympanic membrane, and granulation tissue, which may mimic malignant otitis externa.
* Mastoiditis — may present with systemic illness, fever, marked hearing loss, and mastoid tenderness or swelling.
* Ramsay Hunt syndrome — a form of herpes zoster affecting the facial nerve, which may present with severe pain, vesicles on the external ear canal and posterior pinna, facial paralysis, loss of taste on the anterior two-thirds of the tongue, and decreased lacrimation on the involved side