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Flashcards covering key vocabulary related to learning and memory, including memory types, brain regions, and synaptic mechanisms.
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Memory
The process of retaining information over time.
Classifying Memories – Time Course
Sensory memories last a few seconds, short term memories last a few minutes, intermediate term memories last hours to days, and long-term memory lasts for decades.
Sensory memory
Relies on transient activity in sensory pathways and decays if not moved further.
Short term memories
Used when needed and then discarded.
Memory Consolidation and Recall
Sorting out which memories have the highest emotional significance; memories are flexible before consolidation, and even long-term memories can be disrupted during recall.
Seizure
A sudden surge of electrical activity in the brain that can cause a wide range of symptoms.
Anterograde Amnesia
The inability to form new memories after the event that caused the amnesia.
Declarative (explicit) memory
Memories of facts and events we can consciously recall.
Semantic Memory
Knowledge about words, concepts, and language.
Episodic Memory
Information about events we have personally experienced.
Nondeclarative Memories
Memories that are not part of our consciousness, formed through behaviors.
Procedural Memory
Stores information about how to do things; skills and actions.
Emotional Memory
Learned through emotional conditioning; can be vivid and long-lasting.
Neurotransmitters involved in memory
Epinephrine, Dopamine, Serotonin, Glutamate, Acetylcholine.
Synaptic cleft
The space between the presynaptic and postsynaptic cells, which can be electrical or chemical.
Memory consolidation
Repeated neuron activity leads to increased neurotransmitters in the synapse, resulting in stronger synaptic connections.
Glutamate
The primary excitatory neurotransmitter in the mammalian brain, mediating around 70% of synaptic transmission in the CNS.
Synaptic Plasticity
The ability of the synapse to change in response to increases or decreases in its activity.
AMPA and Kainate receptors
Often coexist on the same neuron; fast action; sodium flows in = excitatory.
NMDA
Requires both glycine and glutamate to be present; slow action; blocked by magnesium, opening depends on membrane voltage.
Early LTP
Lasts for about 1-3 hours and involves increases in AMPA receptors; strengthens already existing synapses.
Late LTP
Lasts for days to weeks (long-term memory); involves the growth of dendritic spines on dendrites by synthesizing new proteins; results in the formation of new synapses.
Parts of the Brain Involved In Memory
Prefrontal cortex, Dorsal striatum, Amygdala, Cerebellum, Hippocampus.
Hippocampus
Recognition memory and spatial memory, involved in memory consolidation.
Subregions of the Hippocampus
Dentate gyrus, Hippocampus proper, Subiculum.
Hippocampal flow of information
Entorhinal cortex → Dentate gyrus → CA3 → CA1 → Subiculum.