Aspirin Flashcards (QAS Drug Protocol)

What is the drug class of aspirin?

Antiplatelet.

What is the pharmacology/MOA of aspirin?

Irreversibly inhibits cyclo-oxygenase → ↓ thromboxane A2 → prevents platelet aggregation.

What does aspirin prevent?

Platelet aggregation at vascular injury sites.

metabolised

Converted to salicylic acid (GI mucosa/liver) → excreted by kidneys.

Indications for aspirin?

Suspected ACS, acute cardiogenic pulmonary oedema.

Contraindication

Aspirin/NSAID allergy or ADR.

Contraindication

Bleeding/clotting disorders (e.g., haemophilia).

What GI conditions contraindicate aspirin use?

Current GI bleeding or peptic ulcer.

Contraindication

<18 years.

surgical concerns, precautions

Possible aortic aneurysm/condition needing surgery.

What is a precaution for aspirin use during pregnancy?

Pregnancy.

precaution for aspirin?

History of GI bleeding/peptic ulcers.

What is a precaution for concurrent anticoagulant therapy?

Concurrent anticoagulant therapy (e.g., warfarin).

common side effects of aspirin?

Epigastric pain, nausea/vomiting, gastritis, GI bleeding, bronchospasm.

What is the presentation of aspirin?

White tablet, 300 mg.

route of administration aspirin

PO (oral).

What is the adult aspirin dose?

≥18 yrs: 300 mg PO.

How is aspirin administered?

Chewed + small sip of water if possible.

What is the onset time for aspirin?

10 minutes

What is the duration of aspirin's antiplatelet effect?

≈1 week.

What is the half-life of aspirin?

3.2 hours (300-650 mg).

scheduling of aspirin?

S2 therapeutic poison.

When should aspirin be given in ACS/APO?

After initial GTN dose (if indicated).

Should aspirin be given if an ACS patient is pain free?

Yes.

What drug family does aspirin belong to?

NSAID (non-steroidal anti-inflammatory drug).

What is the aspirin dose if already taken today?

Total daily dose should equal 300-450 mg if <300 mg taken in previous 24 hrs.