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Development of invasive lobular carcinoma
Duct or acinus in a lobule Cancer cells break out and invade the surrounding tissue in single file
Invasive lobular carcinoma is associated with
Adjacent LCIS (About 2/3)
Unique histological feature of invasive lobular carcinoma
Cells lose their adherent junctions
Cells are in single file strands moving into the stroma
Detection of invasive lobular carcinoma (3)
May be a palpable mass
May be mammographic densities
May be clinically occult breast cancer
Other information on invasive lobular carcinoma
Lymph node involvement/ Metastasis with no detectable primary tumor
Often times does not invoke a vigorous desmoplastic response