COVID-19

What is the active metabolite of Remdesivir and what does it do?

GS-443902; acts as an analogue of ATP , inhibiting RNA-dependent RNA polymerase (RdRp)

What is the predominant circulating metabolite of Remdesivir?

GS-441524

Remdesivir is recommended for treatment of COVID-19 in ______________ who do not require ___________ but are at high risk of progressing, within ___ days of symptom onset.

hospitalized patients, hospitalized patients

Remdesivir can cause ___________ and elevate ___________, so baseline liver function must be evaluated before starting treatment.

hepatotoxicity, aminotransferases

_________ abnormalities can occur when taking ________, and PT helps assess liver synthetic function and bleeding risk.

Coagulation, Remdesivir