Methylprednisolone (Solu-Medrol) Overview

A set of flashcards covering key concepts about Methylprednisolone including its classification, mechanism of action, indications, contraindications, dosing, side effects, and precautions.

Methylprednisolone

A corticosteroid used to decrease inflammation and suppress immune response.

Mechanism of Action

Decreases inflammation by stabilizing leukocyte lysosomal membranes and suppressing pituitary release of corticotrophin.

Indications

Conditions where Methylprednisolone is used include anaphylaxis, asthma/bronchospasm, and exacerbation of COPD.

Contraindications

Systemic infections and septic shock are contraindications for Methylprednisolone use.

Dose

The recommended dosage is 80 to 125mg IV/IM.

Side Effects

Fluid retention, CHF, HTN, abdominal distention, vertigo, headache, nausea, malaise, and hiccups.

Precautions

Only a single dose should be given; long term steroid therapy risks include gastrointestinal bleeding and suppression of adrenocortical steroids.

Methylprednisolone classification

It is classified as a corticosteroid.