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Neurulation
formation of basic brain structures
weeks 3-12
Neurulation:
What time frame during pregnancy does it occur?
Neuronogenesis
neurons develop around lateral ventricles; formation of neurons and glia
months 2-4
Neuronogenesis:
What time frame during pregnancy does it occur?
migration
Neurons and glial cells migrate from lateral ventricles to cerebral cortex; cells move to their proper location
months 3-8
Migration:
What time frame during pregnancy does it occur?
month 6 to 1-2 years postnatal
Organization:
What time frame during pregnancy does it occur?
month 8 to early adulthood
Myelinization:
What time frame during pregnancy does it occur?
Gastrulation
an early stage in embryonic development where a simple, single-layered hollow ball of cells (the blastula) reorganizes into a multi-layered structure
endoderm, mesoderm, ectoderm
What are the three germ layers formed during gastrulation?
endoderm
Which germ layer does the below originate from?
Epithelial linings of the respiratory and alimentary tracts
Glands of GI tract
Glands related to liver and pancreas
mesoderm
Which germ layer does the below originate from?
Skeletal muscles
Blood cells
Lining of blood vessels
mesoderm
Which germ layer does the below originate from?
Majority of cardiovascular system
Cartilage
Bones
Tendons
Ligaments
ectoderm
Which germ layer does the below originate from?
Epidermis
CNS
PNS
Eyes
CT of head
neurulation
formation of the neural plate and neural tube
week 3-4
When does neurulation occur during pregnancy?
neural plate
nervous system begins as a longitudinal thickening of the ectoderm - what is it called?
plate, folds, grooves, tube, crest
In what order do the structures formed during neurulation form?
inside the embryo
Where do the neural tube and crest move after formation?
superior neuropore
Which neuropore typically closes by day 27?
inferior neuropore
Which neuropore closes ~3 days after the first one?
ventricles and central canal of spinal cord
What is the cavity of the neural tube a precursor of?
neural tube
What is the precursor for the ventricles and central canal of the spinal cord?
skull and vertebra
What is the anteromedial part of the somite a precursor of?
anteromedial somite
What is the precursor for the skull and vertebra?
skeletal muscle
What is the posteromedial part of the somite a precursor of?
posteromedial somite
What is the precursor for skeletal muscle?
Dermis
What is the lateral part of the somite a precursor of?
lateral somite
What is the precursor for the dermis?
spinal cord and brain
What are the walls of the neural tube a precursor of?
sensory fibers
What is the alar (dorsal) plate a precursor of?
alar plate
What is the precursor for sensory fibers?
motor fibers
What is the basal (ventral) plate a precursor of?
basal plate
What is the precursor for motor fibers?
day 20-35
timing for development of meninges
Meninges
What develops from cells of neural crest and mesenchyme?
neural crest, mesenchyme
What cells serve as the precursors for the meninges?
week 5
timing for CSF development
late fetal into first prenatal year
timing for myelination
day 28
timing for brain formation
week 26-28
timing for gyri formation
midbrain, forebrain, hindbrain
What are the 3 enlargements for brain formation?
myelencephalon, metencephalon
What does the hindbrain enlargement develop into?
upper medulla, pons, cerebullum, fourth ventricle
What does the metencephalon develop into?
lower medulla
What does the myelencephalon develop into?
midbrain, cerebral aqueduct
What does the midbrain develop into?
Telencephalon
What does the anterior forebrain develop into?
cerebral hemispheres, lateral ventricles
What does the telencephalon develop into?
Diencephalon
What does the posterior forebrain develop into?
thalamus, hypothalamus, third ventricle
What does the diencephalon develop into?
neural migration
epithelial cells lining the neural tube divide to produce neurons and glia; do so by sending processes to the brain and pulling themselves to it or by climbing along radial glia
neuronal redundancy
Allows non-damaged parts of the brain to compensate for loss of function when other parts of the brain are damaged
neuronal pruning
Excess neurons and synapses are created during development, what removes the excess that were not strengthened through use?