NAPLEX Depression

Celexa

citalopram

Lexapro

escitalopram

Prozac

fluoxetine

Paxil

paroxetine

Zoloft

sertraline

Effexor XR

venlafaxine

Pristiq

desvenlafaxine

Which antidepressant is a secondary amine?

nortriptyline

Which antidepressant is a tertirary amine?

amitriptyline, doxepin

Pamelor

nortriptyline

Palmelor drug class

secondary amine

Marplan

isocarboxazid

Nardil

phenelzine

Parnate

tranylcypromine

Marplan drug class

MAOi

Nardil drug class

MAOi

Parnate drug class

MAOi

Which antidepressant is a MAO-B selective inhibitor?

selegiline

Remeron

mirtazapine

Remeron drug class

tetracyclic antidepressant with central presynaptic alpha-2 antagonist effects (increases NE and 5-HT)

Trazadone drug class

inhibits 5-HT reuptake and blocks H1 and alpha-1 adrenergic receptors

Which antidepressant is preferred for patients with cardiac risk?

sertraline

Which antidepressant should be avoided in seizures?

bupropion

Which antidepressants are activating medications and should be taken in the morning?

fluoxetine, bupropion

Which antidepressants are sedating medications and should be taken at night?

paroxetine, mirtazapine, trazodone

Which antidepressant should NOT be used in pregnancy?

paroxetine

Which meds have a lower risk of sexual dysfunction?

bupropion, mirtazapine

Abilify

aripiprazole

Symbyax

olanzapine + fluoxetine

Clozaril

clozapine

Latuda

lurasidone

Zyprexa

olanzapine

Invega

paliperidone

Geodon

ziprasidone

Ritalin

methylphenidate

Concerta

methylphenidate

Vyvanse

lisdexamfetamine

Kapvay

clonidine ER

Intuniv

guanfacine ER

Lunesta

eszopiclone

Restoril

temazepam

Edluar

zolpidem

Which natural products may be helpful for treating depression?

st. john’s wort, SAMe, valerian

Patients with suspected depression should have ________ ruled out because starting antidepressant therapy can induce mania or cause rapid-cycling between depression and mania

bipolar disorder

_____ are often used to treat anxiety (although they are not first-line). When depression and anxiety occur together, _______ should NOT be used alone; ______ can worsen and/or mask depression and can be problematic in patients with concurrent substance use disorders

BZDs

For most patients with depression, an _______ is preferred if there are no special conditions

SSRI, SNRI

Physical symptoms (e.g. low energy) improve within 1-2 weeks but psychological symptoms (e.g. low mood) may take _________

a month or longer

If an antidepressant does not work after a suitable trial of at least ____weeks, treatment should be reassessed (treatment-resistant depression)

4-8

If an antidepressant is necessary in a pregnant patient who was not taking an antidepressant before pregnancy, _______ are first-line options

SSRIs

Although preferred in pregnancy, SSRIs have a warning for risk of ________ when used during pregnancy

persistent pulmonary htn of the newborn (PPHN)

Which type of antidepressant is preferred in post-partum depression?

SSRI

PO Zuranolone (Zurzuvae) indication

C-IV drug for severe post-partum depression

Generally antidepressants should be tapered over several weeks to avoid withdrawal. But which antidepressant is an exception because it self-tapers because of its long half-life?

fluoxetine

The washout period for Fluoxetine when switching from MAOi is _____ weeks, normally it’s 2-weeks with other SSRIs

5

Which SSRIs are also approved for premenstrual dysphoric disorder (PMDD)?

fluoxetine, paroxetine CR, sertaline

Brisdelle

paroxetine capsule for menopause-associated vasomotor sx

What are the warnings for SSRIs + SNRIs?

QT prolongation, SIADH/hyponatremia, fall risk, bleeding

What are the warnings for SNRIs?

SIADH/hyponatremia, fall risk, bleeding

Celexa drug class

SSRI

Lexapro drug class

SSRI

Prozac drug class

SSRI

Paxil drug class

SSRI

Zoloft drug class

SSRI

Which antidepressants are CYP2D6 inhibitors?

fluoxetine, paroxetine, duloxetine

Which antidepressant is preferred to treat vasomotor side effects from Tamoxifen?

venlafaxine

Effexor XR drug class

SNRI

Cymbalta drug class

SNRI

Pristiq drug class

SNRI

Vilazodone (Viibyrd)

SSRI and 5-HT1A partial agonist for depression (take with food, has less sexual SEs than SSRI/SNRIs)

Vortioxetine (Trintellix)

SSRI, 5-HT3 receptor antagonist and 5-HT1A agonist for depression (take with food, has less sexual SEs than SSRI/SNRIs)

Which antidepressants have the additive QT-prolongation risk?

SSRI (citalopram, escitalopram), SNRI (venlafaxine), TCAs, mirtazepine, trazadone

What type of TCA is more selective for NE and have less side effects?

secondary amine

Which type of TCA are less selective, which can contribute to a slightly higher efficacy but more anticholinergic and antihistamine side effects (e.g. sedation, weight gain)

tertiary amine

Which antidepressant should be monitored for suicidal ideation (an intended over dose can quickly cause fatal arrhythmia)?

TCAs

Which antidepressant can cause orthostasis?

TCAs

Which antidepressant can cause weight gain?

TCAs, mirtazepine

Wellbutrin drug class

dopamine + NE reuptake inhibitor

Which antidepressant has a contraindication for history of anorexia/bulimia?

bupropion

Which antidepressant can cause weight loss?

bupropion

Which antidepressant can cause priapism?

trazadone

Abilify drug class

atypical antipsychotic for adjunctive therapy in treatment-resistant depression

Seroquel drug class

atypical antipsychotic for adjunctive therapy in treatment-resistant depression

Symbyax indication

adjunctive therapy in treatment-resistant depression

Esketamine (Spravato)

C-III NMDA receptor antagonist nasal spray for adjunctive therapy in treatment-resistant depression

Aripipazole side effects

insomnia, anxiety, akathisia