LSM3210 L1: digestion, absorption and transport of dietary fats

what are the receptors that carry soluble lipids into the intestinal cells?

FATP4 / CD36

what are the receptors that carry cholesterol into the intestinal cells?

NPC1L1

when TAG + cholesterol come together in the enterocytes, what are they called?

chylomicron

name the drug to combat obesity + how does it work?

tetrahydrolipstatin (THL) → inhibits hydrolysis of TAG → so cannot be absorbed by enterocytes

name the drug to combat high cholesterol

Ezetimibe

• inhibit NPC1L1 (prevent cholesterol uptake by enterocytes)

what are the 5 classes of lipoproteins?

chylomicron, VLDL, LDL, IDL, HDL

what are the 2 drugs that help to lower VLDL in bloodstream?

1. APOB antisense oligonucleotide

2. MTP inhibitor

why are TG-rich lipoproteins bad for our body?

they can trigger atherosclerosis (buildup of fats on the walls of arteries)

what is the order of lipoprotein density from lowest to highest?

lowest density

chylomicron → VLDL → IDL → LDL → HDL

what are the 1 abundant fatty acids in nature?

palmitic & oleic acid