Autoimmune Hemolytic Anemias (ASCPi)
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6 Terms
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Immune hemolytic anemia
It is defined as shortened RBC survival mediated through the immune response (antibodies)
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WAIHA
Autoantibody reacts with patient’s RBC in vivo
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Drug-Dependent or Immune complex (“Innocent Bystander”) Mechanism
Soluble drug-antidrug complex nonspecifically adsorbs loosely to the RBC surface
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Drug adsorption (Hapten)
Drugs such as penicillin or cefotetan bind firmly to
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Drug-independent
Alpha-methyldopa / Adomet induces production of an autoantibody that recognizes RBC antigen.
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Membrane modification
Drugs such as cephalosporins modify the RBCs so that plasma proteins can bind to the membrane nonimmunologically
Note 
Flashcards (37)