Autoimmune Hemolytic Anemias (ASCPi)

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Last updated 9:52 AM on 6/27/26
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6 Terms

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Immune hemolytic anemia

It is defined as shortened RBC survival mediated through the immune response (antibodies)

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WAIHA

Autoantibody reacts with patient’s RBC in vivo

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Drug-Dependent or Immune complex (“Innocent Bystander”) Mechanism

Soluble drug-antidrug complex nonspecifically adsorbs loosely to the RBC surface

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Drug adsorption (Hapten)

Drugs such as penicillin or cefotetan bind firmly to

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Drug-independent

Alpha-methyldopa / Adomet induces production of an autoantibody that recognizes RBC antigen.

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Membrane modification

Drugs such as cephalosporins modify the RBCs so that plasma proteins can bind to the membrane nonimmunologically