27 Illicit drugs

what drug class are methamphetamines

psychostimulant

amphetamines are often used to treat what conditions in humans

obesity, narcolepsy, ADHD

What is the moa of methamphetamine

Norepinephrine release

where does methamphetamine reach the highest concentration

in the brain

what are some clinical signs of methamphetamine toxicity

hyperactivity, agression, hyperthermia, ataxia, tachycardia

what might you see on chemistry and/or blood gas with methamphetamine toxicity

hypoglycemia, metabolic acidosis

what is the treatment of methamphetamine toxicity

oxygen supplementation, fluids, minimal stimulation, supportive

what is the active ingredient of marijuana

THC

what is the moa of marijuana

interaction iwth serotonin, dopamine, actylcholine, norepinephrine

what are some clinical signs of marijuana toxicity

Ataxia, depression, hypothermia, bradycardia, dribbling urine

what can you use to test for illicit drugs

plasma, urine

What are some treatment options for marajuana toxicity

oxygen supplementation, anti-seizure meds, emesis, supportive

Where does methamphetamine tend to reach the highest concentration in the body

brain

what type of receptors does amphetamine have an affinity for

alpha and beta adrenergic receptors

what hormone does amphetamine mediate the release of

noradrenaline/norepinephrine, dopamine, serotonin, glutamate

what does amphentamine prevent the reuptake and metabolism of

catecholamine

What enzymes play a role in cocaine metabolism

serum esterase, hepatic demethylation enzymes

what is the mechanism of toxicity for cocaine

increased catecholamine release, blocked reuptake of NE, serotonin, dopamine, increased concentration of neurotransmitters at synapses, blocked sodium channels, increased intracellular calcium in myocytes

what is the moa of PCP

non-competitive antagonist of NMDA receptors, blocks uptake of dopamine and NE

what receptors does PCP agonistically bind to

acetylcholine, GABA

What receptors does PCP antagonistically bind to

NMDA