25. Hemostasis and hemocoagulation. Vascular, thrombocyte and coagulation haemostasis. Fibrinolysis and anticoagulational mechanisim. Control of haemostasis.

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5 Terms

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✅ 1. Hemostasis (Definition & Phases)

  • Defined as the process that stops bleeding and repairs vessel damage.

  • Differentiates hemostasis (bleeding stop) from hemocoagulation (clotting).

  • Three Phases clearly described:

    • Vascular phase → vasoconstriction via endothelin.

    • Platelet phase → platelet adhesion, activation (ADP, serotonin, thromboxane A₂), plug formation.

    • Coagulation phase → intrinsic/extrinsic pathways → thrombin → fibrin → stabilized clot.

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✅ 2. Coagulation Phase (Hemocoagulation)

  • Explains prothrombin activator → thrombin → fibrinogen → fibrin.

  • Fibrin mesh and fibrin-stabilizing factor are included.

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✅ 3. Fibrinolysis

  • Described as clot degradation.

  • Plasminogen → plasmin → degrades fibrin.

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✅ 4. Anticoagulation Mechanisms

  • Antithrombin, Protein C, Protein S, and Thrombomodulin mechanisms are correctly listed and explained.

  • Includes Vitamin K and heparin effects.

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✅ 5. Control of Hemostasis