BIO1080 - systems biology

https://quizlet.com/ca/568035194/biol-1080-midterm-1-flash-cards/

system biology

study of complex interactions in biological systems,

predicts outcomes and responses

emergent properties

properties that can only be observed when individual components are interacting together

integrative research

a research approach that combines multiple disciplines to understand complex biological systems

reductionist research

a research approach that focuses on smaller and more individual parts of study

genomics

study of organism’s complete DNA set

proteomics

study of a set or all proteins produced within biological unit; can be organ or organ system or entire organism

metabolomics

study of metabolites within given unit

health

state of complete mental, physical, and social wellbeing, not just the absence of disease or weakness

characteristics of life

• ability to reproduce

• growth

• response to stimuli

• made up of cells

• passing of genes to next generation

• metabolism

• homeostasis

biological concepts of health

• each adult human is a unique biological system

• has control and communication network (CCN)

• CCN controls and processes information

• CCN is focal point of health (health depends on how effectively CCN is working) — lifestyle medicine

• aging and disease are processes of compromising function or structure of CCN

• integrated approach should enhance medical and healthcare practice

lifestyle medicine

health care approach using healthy daily habits to prevent and manage chronic disease

8 pillars of lifestyle medicine

• healthy eating

• regular exercise

• restorative sleep

• stress management

• postive social connections

• avoiding risky substance

• hygiene

• positive environmental connection

components of control and communcation network

• central nervous system

• peripheral nervous system

• endocrine system

• support/defence system

p4 medicine

personalized, predictive, preventative, participatory

bioinformatics

mathematical modelling of systems biology

stimulation of fat oxidation in muscle by leptin reductionist vs integrated approach

r: it is an isolated test done without other hormones, so lab data shows leptin oxidizes fat which may help with weight loss
i: leptin has other effects on tissues in the body, so overweight people have lots of leptin but bodies become resistant

observing what limits maximal oxygen uptake reductionist vs integrated approach

r: single leg extensions- studies muscle content limits of oxygen
i: cardiac output (running)- main limiter of oxygen

is the current type 2 diabetes and regulation of glucose a reductionist or integrated approach

reductionist because single blood sample taken at a time and per site, which doesn't explain why blood glucose is elevated

what does the CCN do, what are its characteristics

CCODR (cc odor)
C-COORDINATES/CONTROLS function of all physiological systems and individual organs
C- processes information flow that is chemical based for CELL COMMUNICATION
O- always ON
D- DISTRIBUTED throughout the entire body (glands and cells)
R- high degree of REDUNDANCY (plan B's)

what are the 7 dimensions of health

mental, emotional, physical, occupational, social, environmental, spiritual