Caspi et al.

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Last updated 6:33 PM on 4/30/26
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6 Terms

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Aim

The impact of a functional change of the 5HTT gene on higher or lower depression in an individual

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Participants

847 26 year olds from New Zealand who had been studied for their mental health since childhood

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Method

Correlational Study

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Procedure

3 groups depending on the 5HTT gene:

1) Two short

2) One short, one long

3) Two long

Asked the participants about stressful life situations

Diagnostic criteria to evaluate depression

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Results

One or two short alleles: More likely to develop depression with a stressful life event

2 long alleles: Less likely to develop depression

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Findings

Environmental stress AND biological factors raise risk of depression

  • supports the Diathesis-Stress Model for depression