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skeletal cartilage
made of highly resilient, molded cartilage tissue that consists primarily of water, and contains so blood vessels or nerves
perichondrium
layer of dense ct surrounding cartilage like a girdle; it helps cartilage resist outward expansion and contains blood vessels for nutrient delivery to cartilage
Cartilage makeup
made of chondorcytes, cells encased in small cavities (lacunae) within jelly0like extracellular matrix
what are the three types of cartilage
hyaline, elastic, and fibrocartilage
hyaline cartilage
provides support, flexibility, and resilience; most abundant type, contains collagen fibers
where is hyaline found
articular joints, costal ribs, respiratory larynx, and nasal cartilage in the tip of the nose
elastic cartilage
similar to hyaline cartilage, but contains elastic fibers, and is found in the external ear and epiglotis
fibrocartilage
thick collagen fibers; has great tensile strength; found in the menisci of knee and vertebral discs
what are the 2 ways cartilage grows
appositional growth, and interstitial growth
appositional growth
cartilage forming cells in perichondrium secrete matrix against external face of existing cartilage; the new matrix is laid down on surface of cartilage
intersitial growth
chondrocytes within lacunae divide and secrete new matrix, expanding cartilage from within; new matrix is made within cartilage
when does classification of cartilage occur
during normal growth in youth, but can also occur in old age
how many bones are in the body and how are they divided
206 and divided into two groups based on location and also by shape
axial skeleton
long axis of body (ex skull, vertebral column, rib cage)
appendicular skeleton
bones of upper and lower limbs(ex girdles attaching limbs to axial skeleton)
long bones
longer than they are wide, have a shaft and two ends (ex, limb bones)
short bones
cube shaped bones (in wrist and ankle) (ex. sesamoid bones form within tendons like patella)
flat bones
thin flat, slightly curved (ex. sternum, scapulae, ribs, and most skull bones)
irregular bones
complicated shapes (ex. vertebrae and hip bones)
what are the 7 functions of bones
support, protection, movement, mineral and growth factor storage, blood cell formation, triglyceride storage, and hormone production
support
for body and soft organe
protection
protects brain, spinal chord, and vital organs
movement
levers for muscle action
mineral and growth factor storage
calcium and phosphorous and growth factors reservoir
blood cell formation
aka hematopoiesis; which occurs in red marrow cavities of certain bones
fat storage
fate used for energy source, is stored in bone cavities
hormone production
osteocalcin secreted by bones helps to regulate insulin secretion, glucose levels, and metabolism
compact bone
dense outer layer on every bone that appears smooth and solid; is covered externally by the periosteum
spongy bone
made up of a honeycomb of small, needle-like or flat pieces of bone called trabeculae, and the open spaces between the trabeculae are filled with red or yellow bone marrow. spongy bone is covered by the endosteum
structure of short irregular flat bones
consists of plates of spongy bone (dipole) covered by compact bone. the compact bone is sandwiched between connective tissue membranes: the periosteum which covers the outside of compact bone and the endosteum which covers the inside portion of compact bone; bone marrow is scattered throughout spongy bone and there is no defined marrow cavity; hyaline cartilage covers area of bone that is part of a movable joint
flat bone structure
consists of a layer of spongy bone sandwiched between 2 thin layers of compact bone
structure of typical long bone
all have a shaft (dyaphisis), both ends (epiphyses), and membranes
dyaphysis
tubular shaft that forms along axins of bone and consists of compact bone surrounding central medullary cavity that is filled with yellow marrow in adults
epiphyses
ends of long bones that consist of compact bone externally and spongy bone internally; articular cartilage covers articular joint surfaces
epiphyseal line
between the diaphysis and the epiphysis. remnant of this plate where bone growth occurs, the thicker it is the younger the person is
periosteum
white double layered membrane that covers external surfaces except joints; contains many nerve fibers and blood vessels that continue on to the shaft through nutrient foramen openings
what are the 2 layers of the periosteum
fibrous layer and osteogenic layer
fibrous layer
outer layer consisting of dense irregular connective tissue consisting of sharpeys fibers that secure to bone matrix
osteogenic layer
inner layer abutting bone that contains primitive osteogenic stem cells that gives rise to most all bone cells
osteoblasts
build new bone
osteocytes
eat or destroy bone
endosteum
delicate connective tissue membrane covering internal bone surface; it covers the trabeculae of spongy bone, and lines canals that pass through compact bone. like periosteum, contains osteogenic cells that can differentiate into other bone cells, osteoblasts, and osteoclasts
red marrow
found within trabecular cavities of spongy bone and dipole of flat bones, such as the sternum. in newborns the medullary cavities and al spongy bone contain red marrow, whereas In adults red marrow is located in the heads of the femur and humorous, but most active areas of homatopoeisis are flat bone dipole and some irregular bones such as the hip bones
yellow marrow
fat storage; can convert to red marrow id a person becomes anemic
bone markings
sites of muscle, ligament, and tendon attachment on external surfaces, areas involved in joint formation or conduits for blood vessels and nerves
what are the 3 types of bone markings
prokection, depression, and openings
projection
outward bulge of a bone; may be due to increase stress from muscle pull or is a modification for joints
depression
bowl or groove-like cut out that can serve as passageways for vessels and nerves, or plays a role in joints
opening
hole or canal in bone that serves as passageways for blood vessels and nerves
bone marking surfaces that help to form joints
head, facet, condyle
head
bony expansion carried on a narrow neck
facet
smooth, nearly flat articular (joint) surface
condyle
rounded articular projection; often articulates with a corresponding fossa
depression and opening bone markings for passage of blood vessels and nerves
groove, fissure, foramen, notch
groove
furrow
fissure
narrow, slit like opening
foramen
round or oval opening through a bone n
notch
indentation at the edge of a structure
depressions and openings bone markings with other functions
meatus, sinus, fossa
meatus
canal like passageways
sinus
cavity within a bone, filled with air and lined with mucous membrane
fossa
shallow basin-like depression in a bone, often serving as an articular surface
projections that are sites of muscle and ligament attachment
tuberosity, crest, trochanter, line, tubercle, epicondyle, spine, and process
tuberosity
large rounded projection; may be roughened
crest
narrow ridge of bone; usually prominent
trochanter
very large, blunt, irregularly shaped process (only examples are on the femur)
line
narrow ridge of bone; less prominent than a crest
tubercle
small rounded projection or process
epicondyle
raised area on or above a condyle
spine
sharp, slender, often pointed projection
process
any bony prominence
osteogenic cells
mitotically active stem cells in periosteum and endosteum
osteocytes
maintain bone matrix, produce matrix for remodeling of bone
compact bone
also called lamellar bine (circle/tree trunk) which consists of osteomyelitis (aversion system), canals and canaliculi, intersitial and circumferential lamallae
osteon (aversion system)
is the structural unit of compact bone. consists of an elongated cylinder that runs parallel in alternating layers to long axis of bone and acts as tiny weight bearing pillars.
osteon cylinder
consists of several rings of bone matrix called lamellae which contain collagen fibers that run in different directions in adjacent rings. the cylinder withstands stress and resists twisting. bone salts are found between collagen fibers
central canal (haversion)
runs through core of osteomyelitis, contains blood vessels and nerve fibers
perforating (Volkman’s) canals
canals lined with endosteum that occur at right angles to central canal; it connects blood vessels and nerves of periosteum, medullary cavity, and central canal
lacunae
small cavities that contain osteocytes
canaliculi
hair like canals that connect lacunae to each other and to central canal
intersitial lamellae
lamellae that are not part of osteon but fill in gaps between osteon
circumferential lamellae
just deep to periosteum, but superficial to endosteum, these layers of lamellae extend around entire surface of diaphysis (helps long bone to resist twisting)
organic components of bone
includes osteogenic cells, osteoblasts, osteocytes, bone-lining cells, osteoclasts, and osteoid
osteoid
makes up 1/3 of organic bone matrix is secreted by osteoblasts. consists of ground substance and collagen fibers, which contribute to high tensile strength and flexibility of bone
inorganic compounds
hydroxyapatite (mineral salts) which consist mainly of tiny calcium phosphate crystals in and around collagen fibers; responsible for hardness and resistance to compression
growth hormone
most important hormone in stimulating epiphyseal activity in infancy and childhood
thyroid hormone
modulates activity of growth hormone, ensuring proper proportions
testosterone and estrogen at puberty
promote growth spurts and ends growth by inducing epiphyseal plate closure
bi=one remodeling
consists of both bone deposit and bone resorption
resportion
function of osteoclasts which: form big depressions or grooves as they break down the matrix, secrete lysosomal enzymes and protons that digest the matrix, acidity converts calcium salts to soluble forms, osteoclasts also phagocytize demineralized matrix and dead osteocytes. once resorption is done osteoclasts go through apoptosis
osteoclas activation
parathyroid hormone and immune T cell proteins
bone deposit
new bone matrix is deposited by osteoblasts which occurs wherever bone is injured or added strength is needed. Hydroxyapatite, mainly calcium phosphate eventually crystalize with the help of matrix proteins and the enzyme alkaline phosphate which is shed by osteoblasts
parathyroid hormone
produced by parathyroid glands in response to low blood calcium levels. stimulates osteoclasts to resorb more, calcium is released into blood, raising levels, and pth secretion stops when homeostatic calcium levels are reached
calcium
produced by parafollicular cells of thyroid gland in response to high levels of blood clacium levels
response to mechanical stress
bones are stressed when weight bears on them or muscles pull on them
wolfs law
states that bones grow or remodel in response to demands placed on them
what underlines nearly every bone disease
imbalances between bone deposit and bone resorption
osteomalacia
inadequate mineralization, that causes soft bones
rickets
osteomalacia in children: both caused by insufficient calcium in diet or vitamin d deficiency
osteporosis
group of diseases where bone resorption outpaces bone deposit