Module 12: Obesity and Lipid Storage Diseases

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Obesity

It is a body condition characterized by the excessive accumulation of fat in the body, particularly in the adipose tissues beneath the skin and within other organs, including muscles

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Obese

A person can be categorized _______ if he/she is overweight or has an abnormal increase in body weight beyond that is considered desirable with regards to age, height and bone structure

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Atherosclerosis

a form of Arteriosclerosis ("hardening of the arteries") due to the formation of abnormal masses of fatty or lipid material (atheroma) within the intima or inside the lumen of arteries resulting to obstruction to the blood supply and eventual dysfunction of these blood vessels

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Arteriosclerosis

it is the hardening of the arteries

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atheroma

due to the formation of abnormal masses of fatty or lipid material

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Hypertension

persistently high pressure of the blood against the arterial walls

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Myocardial infarction

it refers to the death or necrosis of the cells of an area of the heart muscle (myocardium) as a result of oxygen deprivation due to blood supply obstruction which can lead to death

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Myocardial infarction

commonly referred to as "heart attack"

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myocardium

referred as the heart muscle

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Diabetes mellitus (type II)

due to a decreased sensitivity of the body tissues to insulin

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Osteoarthritis

frequent sensation of chronic back and joint pains from increased strain on joints and ligaments

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Diaphoresis

excessive or profuse secretion of sweat

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Halitosis

offensive odor of the breath due to rancidity of fats in the throat

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Vaginal candidiasis (for obese females) and body odor

since a fatty environment can be accessible to culture microorganisms like fungi and bacteria

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Amenorrhea (secondary)

absence of the onset of menstruation which may lead to sterility

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Lipemia retinalis

manifestation of a milky appearance of the blood vessels due to excess fat in the blood which can result to blurredness of sight and eventual blindness

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Lipomatosis

condition characterized by abnormal localized or tumor – like accumulations of fat in the tissues

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Immunosusceptibility

increased physical defenselessness or a greater tendency to contract infectious diseases

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Intestinal bypass (Jejunoileal shunt)

the proximal jejunum and terminal ileum are bypassed in order to bring about malabsorption of digested food

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Jejunoileal shunt

other name for Intestinal bypass

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Liposuction

aspiration of excess fat usually in the subcutaneous tissues

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Lipid storage diseases

are a group of inherited metabolic disorders in which harmful amounts of fatty materials called lipids accumulate in some of the bodys cells and tissues

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Lipidoses

other name for Lipid storage diseases

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to help treat pain (including bone pain) for patients with Fabry disease

The drugs phenytoin and carbamazepine may be prescribed

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Glucocerebrosidase deficiency

Gaucher’s disease

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Sphingomyelinase deficiency

Niemann – Pick’s disease

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Alpha – galactosidase – A deficiency

Fabry’s disease

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Ceramidase deficiency

Farber’s lipogranulomatosis

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Beta – galactosidase deficiency - GM1

gangliosidosis

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Beta – hexosaminidase deficiency

Tay – Sachs’ disease

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Galactosylceramidase deficiency

Krabbe’s disease

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Arylsufatase – A deficiency

Metachromatic leukodystrophy

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Acid lipase deficiency

Wolman’s disease

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Fucosidosis

Alpha – fucosidase deficiency

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Enzymes

Lipid storage diseases are classified into different types according to?

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