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influenza transmission
droplet
3 major strains of influenza
A,B,C
what is the goal of influenza antibiotics
the antibodies build to prevent severity
allergic reactions to flu vaccine
egg allergy
flu s/s
muscle weakness, stuffy nose, N/V, diarrhea, fatigue, and chills
adults are contagious - flu
24 hours before symptoms and 5 days after they start
what are you checking in the CBC for influenza
lymphocytes
medications for influenza
antivirals, antipyretics, antitussives, antihistimines, and analgesics
does influenza or a common cold run a higher fever
influenza
how is MRSA developed
due to antibiotics being given at higher doses and for longer period of time than were necessary
why is MRSA difficult to treat
antibiotic therapy may increase the growth of microbes within biofilms
what patients are most at risk for developing MRSA
long history of antibiotics, invasive tubes/lines(biofilms), and immunocompromised
how is MRSA transmitted
contact
is MRSA curable
once you get it you always have it
treatment for health care associated MRSA
vancomycin, linezolid, and IV ceftaroline
health care associated MRSA
patients and health care staff may be colonized, invades through tubes/lines, can quickly lead to sepsis
community associated MRSA
infections in healthy people, can cause serious skin and soft-tissue infections
meds to treat community associated MRSA
minocycline and doxycycline
what is cellulitis
localized area of inflammation, may spread rapidly if not treated
what can cause cellulitis
minor skin trauma that doesn’t heal right
how can cellulitis spread
scratching
s/s cellulitis
redness, warmth, edema, tenderness, and pain
risk factors of cellulitis
injury, weak immune, skin conditions (secondary infections), chronic swelling (skin may crack), history, and obesity
TB transmission
airborne
what is TB
bacteria multiplies in bronchi or alveoli, when you cough it spreads
TB s/s - adults
fatigue, lethargy, nausea, anorexia, weight loss, fever, night sweats, cough with blood, and chest tightness
TB s/s - infants
persistant cough, weight loss, failure to gain weight, and low grade fever
TB s/s - children
fatigue, cough, low appetite, weight loss/growth delays, night sweats, chills, fever, and enlarged lymph notes
immunization for TB
not as effective in adults, BCG vaccine
TB screening
Mantoux (PPD), must be checked 48-72 hours after
what is a positive finding on the PPD test
greater than 15mm (general), greater than 10mm (LTC), greater than 5mm (HIV)
other TB screenings
sputum test, QuantiFERON (24hrs), and chest x-ray
abnormal electrolytes with TB
ABG and PFT
first line TB treatment
isoniazid and rifampen
additional TB meds
ethambutol and pyrazinamide
most common lab technique for TB
acid staining
what does a positive mantoux test show
contact with the bacteria, not active tb
SIRS
systemic inflammatory response syndrome
SIRS patho
body’s response to critical illness that results in a whole body inflammatory process
what infections lead to sepsis
almost any infection can lead to sepsis
SIRS criteria - 2 or more with s/s
temp above 100.4 or below 96.8, heart rate above 90, respirations above 20, abnormal WBCs (4,000-12,000)
SIRS s/s
hypotension, low UO, decreased cap refil, hyperglycemia, mental status change, and rising creatinine
sepsis complications
ARDS, acute renal failure, DIC, MODS, and GI complications
sepsis vitals
low BP, high heart rate, low O2, low LOC, decreased kidney function, and BUN
hallmark sign of sepsis
lactate level above 4
sepsis 1 hour bundle
draw lactic acid, collect culture, broad spectrum antibiotics, fluids, and vasopressors (keep MAP greater than 65, raise BP)
equation for MAP
(diastolic x 2) + systolic / 3
sepsis 24 hour bundle
must be started at same time as 6hr bundle, assess for recombinant APC, low dose steroids, glycemic control, and low tidal volume vent
homeostasis
the constant movement of fluids and electrolytes to maintain a balance in the body
degree of concentration
osmolality
solvent
the water portion of fluids
solute
the particles dissolved in the water
hydrostatic pressure
pushes water back and fourth for equilibrium, water moves through membrane from high pressure to low pressure
diffusion
solute from high concentration to low
osmosis
water molecules move through membrane unti equilibrium is established
active transport
solutes from low to high, goes against gradient
filtration
movement across membrane by pressure from high to low