Chapter 15- DNA and the Gene: Synthesis and Repair

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Xeroderma pigmentosum

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Xeroderma pigmentosum

________ (XP) is a rare autosomal recessive disease in humans.

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topoisomerase

A(n) ________ is an enzyme that cuts DNA, allows it to unwind, and rejoins it.

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Mismatch repair

________ is a form of error correction that cleans up errors introduced during DNA synthesis.

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Telomerase

________ catalyzes the synthesis of DNA using an RNA template that is an integral part of the enzyme.

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RNA primer

Once the ________ is removed and replaced by DNA, an enzyme called DNA ligase catalyzes the formation of a phosphodiester bond between the 3 and 5 ends of adjacent Okazaki fragments, closing up the backbone.

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eukaryotic chromosome

The region at the end of a(n) ________ is called a telomere.

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Deoxyribonucleotides

________ link together into a polymer when a hydroxyl group on the 3 'carbon of one deoxyribose and the phosphate group attached to the 5 carbon of another deoxyribose are joined by a covalent bond called a phosphodiester linkage, or phosphodiester bond.

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gamete formation

Any cell not involved in ________ is a somatic cell.

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exterior protein

During the infection, the ________ coat, or capsid, of the virus is left behind on the exterior of the host cell.

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enzyme

A(n) ________ called telomerase replicates telomeric DNA.

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bacterial cells

Like all organisms, ________ copy their entire complement of DNA,their genome, before every cell division.

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potential energy of the deoxyribonucleotide monomers

The ________ is first raised by reactions that add two phosphate groups to form deoxyribonucleoside triphosphates (dNTPs)

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replication fork

A(n) ________ is the Y- shaped region where the parental DNA double helix is separated into single strands and copied.

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ability of DNA

The ________ polymerase to recognize and remove an incorrect deoxyribonucleotide is called proofreading.

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Semiconservative replication

________: If the parental strands of DNA separated, each one could then be used as a template for the synthesis of a new daughter strand.

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Mismatch repair

________ is the final layer of error detection and correction for errors introduced during DNA synthesis.

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deoxyribonucleotide

Each ________ consists of a deoxyribose sugar, a phosphate group, and a nitrogenous base.

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Semiconservative replication

If the parental strands of DNA separated, each one could then be used as a template for the synthesis of a new daughter strand

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Conservative replication

If the bases of both strands temporarily turned out from the helix, they could serve as a template for the synthesis of an entirely new double helix all at once

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Conservative replication

If the bases of both strands temporarily turned out from the helix, they could serve as a template for the synthesis of an entirely new double helix all at once.

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Dispersive replication

This proposed that the parental double helix was fragmented into small pieces before replication and then each piece was replicated by either a conservative or semi conservative mechanism.

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DNA polymerase

The initial breakthrough on DNA replication came with discovery of an enzyme called

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Primer

A short strand of RNA called a primer that is base-paired to the DNA template

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Phosphodiester linkage or Phosphodiester bond

Deoxyribonucleotides link together into a polymer when a hydroxyl group on the 3' carbon of one deoxyribose and the phosphate group attached to the 5’ carbon of another deoxyribose are joined by a covalent bond called a

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Capsid

During the infection, the exterior protein coat, or capsid, of the virus is left behind on the exterior of the host cell

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