Oncology medications;ALKYLATING AGENTS NITROGEN MUSTARDS: CYCLOPHOSPHAMIDE (PO, IV)

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6 Terms

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Mechanism of action CYCLOPHOSPHAMIDE

Alkylates cellular DNA killing rapidly growing cells 

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therapeutic use

  • Acute lymphomas

  • Solid tumors

  • Non-Hodgkin’s & Hodgkin’s lymphoma

  • Multiple myeloma

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complications

  • Bone marrow suppression

  • N/V

  • Acute hemorrhagic cystitis

  • Alopecia

  • Sterility

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contraindications

  • Pregnancy and lactation

  • Clients with severe infections

  • Use with caution in clients with kidney disorder, liver disorder, leukopenia

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drug to drug interactions

  • Allopurinol, ACE inhibitors & thiazide diuretics

  • Doxorubicin

  • Anticoagulants

  • St John’s wort 

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nursing education

  • Push PO fluids; 2-3 L/day

  • Reduce dose with liver disease

  • Perform good mouth care

  • Use birth control during tx

  • Monitor for hematuria, may need to administer Mesna (uroprotectant)