Week 4- DMS 212 Malignant Diseases

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165 Terms

1

adenocarninoma

malignant tumor arising from any glandular organ

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2

androstenedione

naturally occurring steroid hormone used to increase serum testosterone levels

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3

antiestrogen

Any substance that blocks or modifies the action of estrogen

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4

brachytherapy

procedure that involves placing radioactive material inside the body to treat cancer

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5

cervical stenosis

narrowing or obstruction of the cervical canal

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6

choriocarcinoma

metastatic trophoblastic neoplasia that can result from any preg but mostly occurs with molar preg

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7

endometrial carcinoma

malignant layer of cells form in the endo

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8

endometrial carcinoma presents as

abnormal thickening of endo, irregular bleeding

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9

endometrial hyperplasia

results from estrogen stimulation to the endometrium without progestin and frequent cause of abnormal uterine bleeding in postmenopausal women

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10

endometrial polyp

pedunculated or sessile mass growing from endo

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11

sessile

connect w/o stalk

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12

endometroid

tumor that resembles endo tissue

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13

epithelioid trophoblastic tumor

Variant of placental site trophoblastic tumor

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14

fallopian tube carcinoma

malignancy of fallopian tube

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15

fallopian tube carcinoma is linked to

BRC-A-1 and BRC-A-2

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16

what is the most common type of fallopian tube carcinoma

adenocarcinoma

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17

gadolinium

contrast used in MRI

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18

gestational trophoblastic neoplasia (GTN)

group of rare diseases; when abnormal trophoblast cells overtake and complicate preg and propagate through the uterus

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19

where does GTN arise from

placental chorionic villi after conception

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20

Persistent Trophoblastic Neoplasia (PTN)

malignant from of GTN

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21

granulosa cell tumor

estrogen releasing tumor that arises from granulosa cells

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22

granulosa cell tumor characteristics

large complex ovarian masses

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23

human chorionic gonadotropin (hCG)

hormone produced by chorionic cells in the fetal part of placenta during pregnancy

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24

hCG can cause

morning sickness / vomiting

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25

when would you expect to find elevated hCG levels

GTN

multiple preg

fertility treatment

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26

human papillomavirus (HPV)

sexually transmitted disease that causes lesions on the mucous mems

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27

what is the most common STD

HPV

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28

_________ is a causative factor in cervical carcinoma

HPV

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29

hydrops tubae profluens

Watery discharge sometimes present with fallopian tube carcinoma

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30

invasive mole

type of GTN deriving from a hydatidiform mole that invades the myometrium

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31

leiomyoma

benign tumors composed of smooth muscle and fibrous CT

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32

leiomyosarcoma

malignant uterine tumor composed of smooth muscle and fibrous CT

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33

leiomyosarcoma appears the same as a _______________ on US

leiomyoma

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34

metastases

Transfer of a cancerous lesion from one area to another

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35

methotrexate

drug that inhibits cellular repro

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36

methotrexate can be used to treat

psoriasis

various malignant neoplastic diseases

immunosuppressive agent

ectopic preg

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37

pelvic inflammatory disease

infection of the uterus, fallopian tubes and adjacent pelvic structures

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38

Papanicolaou (Pap) smear

cytology study used to detect cancer

-most often used to prevent/diagnose cervical cancer

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39

pelvic inflammatory disease is a pelvic infection usually caused by...

an ascending infection of vagina/cervix

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40

Persistant Trophoblastic Neoplasia (PTN)

malignant form of GTN most often from molar preg

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41

placental site trophoblastic tumor (PSTT)

type of PTN that usually occurs several years after a normal pregnancy

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42

PCOS involves symptoms such as...

infrequent or irregular menses

excess male hormones

oligo or anovulation

enlarged ovaries w/ numerous peripheral sub centimeter follicles

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43

polypoid

Growth similar to a polyp

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44

radiation therapy

cancer treatment that uses high doses of radiation to kill and shrink cancer cells

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45

raloxifene

drug that blocks hormone receptors to reduce breast cancer risk

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46

resisitive index

used to assess vasc flow resistance

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47

why is resistive index important when differentiating benign lesions from malignant lesions

malignant lesions are usually low RI

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48

sonohysterography

injection of saline into uterus under US guidance to identify endo pathology (polyps)

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49

squamous cell carcinoma

slow-growing malignant tumor composed of squamous epithelium

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50

what is the most common type of cervical cancer

squamous cell carcinoma

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51

tamoxifen

nonsteroidal antiestrogen compound used for cancer treatment of breast cancer

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52

tamoxifen can cause

endometrial hyperplasia

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53

teratogenic

Causing congenital anomalies or birth defects

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54

what is the most common gynecologic cancer on the US

endometrial carcinoma

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55

what are some rick factors for endometrial carcinoma

obesity

nulliparity

late menopause

adenomatous polyps

family hx

unopposed estrogen

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56

S/S of endometrial carcinoma

uterine bleeding, pain

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57

sonographic findings of endometrial carcinoma

heterogenous endo

irregular or poorly defined endo

cystic changes

hydrometra or hematometra

enlarged ut

lobular contour ur

endo thickening

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58

endometrial carcinoma usually occurs in the __________decade of life

6 to 7th

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59

treatment of endometrial carcinoma

total hysterectomy

lymphadenectomy

radiation and chemo

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60

total hysterectomy is the removal of

uterus

ovaries

tubes

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61

diagnostic features of endometrial carcinoma on TV imaging

endo thickness, texture, vascularity

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62

Stage I or II endometrial carcinoma

confined to the ut

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63

stage III or IV endometrial carcinoma

Extends beyond the uterus

Bladder/rectum infiltration

Adjacent mass

Ureteral obstruction

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64

doppler of endometrial carcinoma

increased flow inside lesion

low RI

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65

technique for imaging endometrial cancer

endo thickness measurement

power doppler

uterine and cervix echogenicity

ascites

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66

diagnosis criteria for endometrial cancer

sub endometrial halo irregularity

fluid

vessel architecture/branching pattern

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67

in a pt with suspected endometrial cancer what might be some other organs to image

liver

abdominal viscera

kidneys

para aortic/caval adenopathy

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68

MRI or CT may be better for imaging what types of endometrial carcinoma

lymphadenopathy

metastatic disease (stage III and IV)

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69

endometrial cancer differential diagnosis

endo hyperplasia

endo polyps

leiomyoma

cervical cancer

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70

_______________________________ are extremely rare

leiomyosarcomas

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71

risk factors for leiomyosarcomas

nulliparity, 40yrs and older, obesity, pelvic radiation, tamoxifen

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72

S/S of leiomyosarcomas

vaginal bleeding

abdominal pain

rapid increase in mass size

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73

sonographic findings of leiomyosarcomas

rapidly growing heterogenous mass

single

large

acoustic enhancement

anechoic or complex areas due tumor liquefaction

increase intra tumoral flow

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74

leiomyosarcomas are normally located where inside the uterus

intramural

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75

appearance of leiomyosarcomas

fleshy

hemorrhagic/necrotic

infiltrative borders

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76

treatment of leiomyosarcomas

total hysterectomy

peritoneal washing

nodule sampling

radiotherapy

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77

sonographic technique for imaging leiomyosarcomas

uterine mass echotexture

adnexal masses

free fluid

para aortic/caval area for adenopathy

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78

other imaging modalities that may be helpful when identifying leiomyosarcomas may include

MRI

CT

FDG-PET

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79

differential diagnoses for leiomyosarcomas

other uterine sarcomas

endo adenocarcinoma

adenomyomas

GI cancer

bladder cancer

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80

____________________ is known to be rare, aggressive, and to occur in the 6th decade of life

fallopian tube carcinoma

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81

risk factors of fallopian tube carcinoma

over 40, BRCA chromosomal mutations, infertility, nulliparity, low parity, PID, family hx of ovarian cancer

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82

S/S of fallopian tube carcinoma

elevated CA-125

vaginal bleeding/spotting

abdominal pain

abdominal or pelvic mass

ascites

hydrops tubae profuens

postmenopausal bleeding or spotting w/ neg PAP smear

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83

sonographic findings of fallopian tube carcinoma

cystic mass w/ mural nodules and hydrosalpinx

ill-defined or sausage shaped mass

multilobular mass

pelvic ascites

neovascularization

tubal wall irregularities

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84

clinical diagnoses of fallopian tube carcinoma

asymptomatic or abdominal pain

increased abdominal girth

vaginal bleeding

palp mass

hydrops tubae profluens

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85

hydrops tubae profluens

profuse watery vaginal discharge

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86

treatment of fallopian tube carcinoma

hysterectomy

peritoneal biopsy

lymph node sampling

radiation/chemo

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87

hydrosalpinx

water in the fallopian tube

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88

in a pt with suspected fallopian tube carcinoma what might be some other organs to image

kidneys

liver

abdominal viscera

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89

differential diagnoses of fallopian tube carcinoma

ovarian carcinoma

myoma

PID

other adnexal masses

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90

__________________ is becoming less prevalent and occurs in the 3rd to 4th decade of life

carcinoma of the cervix

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91

risk factors for carcinoma of the cervix

HPV, early sexual activity, multiple partners, smoking, oral contraceptives, weak immune system, DES exposure

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92

S/S of carcinoma of the cervix

asymptomatic

postcoital bleeding

superficial mass on cervix

watery vaginal discharge

back pain

bladder irritability

ureteral obstruction

uremia

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93

sonographic findings of carcinoma of the cervix

normal appearance in stage I and II

hematometra

multiple cystic areas

bulky cervix

irregular cervical borders

hydronephrosis

liver metastasis

para-aortic nodules

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94

treatment of carcinoma of the cervix

cone biopsy

radiotherapy

surgery

radiotherapy/chemo

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95

the American cancer society recommends ____________________ to prevent HPV and further prevent carcinoma of the cervix

Gardasil

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96

Stage I and II carcinoma of the cervix

normal size/echogenicity

hematometra due to cervical stenosis

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97

Stage III and IV carcinoma of the cervix

bulky cervix

bladder invasion

hydro

liver metastasis

para aortic/caval nodes

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98

what are some other types of US used to image carcinoma of the cervix

translabial

transperineal

TV

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99

differential diagnoses of carcinoma of the cervix

lower uterine segment leiomyoma

benign endo polyp

endo cancer

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100

types of GTN's

benign hydatidiform mole

invasive mole

choriocarcinoma

placental site trophoblastic tumor (PSTT)

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robot