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Winemaking Origins
=Origins of Civilization
*Sumer ~6000 BC
-Wine is older than recorded history
What color was the majority of wine in ancient Egypt?
red
-related to the blood of Osiris, god of resurrection
King Tut and wine
died in 1330 BC
6/26 jars in tomb contained white wine from Nile Delta
Dionysus
the god of the grape harvest, winemaking and wine, of ritual madness, fertility, theatre and religious ecstasy in ancient Greek religion and myth.
Eleutherios
"the liberator"
Who was a serious viticulturist?
Odysseus' dad
What was the ancient roman's view of wine?
democratic view
-wine as medicine
-made wine large scale
-stored in amphoras
Amphoras
ceramic vases with handles and a narrow neck
What is wine?
rotting fruit
-it has informed science
What is yeast?
Diverse group of fungi characterized by having a unicellular growth habit
2 types of cell division
1. budding: extrusion of daughter cell from mother cell
2. Fission: division of mother cell into 1+ cells by localized ingrowths
How did taxonomists first define yeast
Morphological and physiological characteristics
Fermentation
Process by which cells release energy in the absence of oxygen
-Saccharomyces cerevisiae process the most common fermentation pathway: alcoholic fermentation
one result of fermentation
*HEAT
What is the avg consumption of caffeine worldwide?
76 mg per person per day
Caffeine in the US
Primarily consumed through soft drinks
-US/Canada: 210-238 mg per person per day
Caffeine in Asia
primarily consumed through tea (except south korea-Coffee)
Who consumes the most coffee per capita
Sweden/finland:
-over 400 mg per person per day
Coffee discovery
traced back to ethiopia (850 AD)
The story of the origin of coffee
A goat herder noticed the effects of arabica plant berries on his herd
Range of coffee
East Africa-Southern Arabia, to 27 mil acres of tropical highland (Africa, East Asia, Hawaii, Central/South America)
Discovery of tea
China- ~1000 BC
-originated in Southwest China
-presently grown on ~10 mil acres, from India to Japan
Coffea Arabica
Most common, sweeter, less acidic, hard to grow
-the most common in North America
Coffea Robusta
2nd most produced
-Common in Europe
-strong flavor, high levels of caffeine, easier to grow
Coffea Liberica
Rare (now)
-grown in specific environments
-"woody" taste, not enough production
Coffea Excelse
technically a variety of liberica
-grown mostly in southeast Asia
-tart and fruity flavor
Camellia Senesis
Tea
-native to southern Japan
-black, green, and white tea all come from the same plant
Caffeine is an Alkaloid
secondary metabolite, plays role in plant defense
-high doses = lethal to insects
-bitter flavor discourages herbivory
-may inhibit germination of plants
Caffeine absorption
Rapidly absorbed through small intestine; peak at 30 min
-readily penetrates blood-brain barrier
-primarily metabolized in liver
-antagonizes same receptors as adenosine (blocks "chill" effect)
Bees and caffeine
-poorer memory = less caffeine
-better memory = more caffeine
Spotlight Consciousness
Single focal point of attention (good for reasoning)
lantern consciousness
Broader field of attention
Homozygous AA
Fast metabolizers
Heterozygous AC and Homozygous CC
Slow metabolizers
Cannabis
The botanical name of a genus within the Cannabaceae family (also contains: hops)
Cannabis contains what 3 species?
1. C. Sativa
2. C. Ruderalis
3. C. Indica
What is the commonality between the 3 species?
All contain secondary compounds:
-cannabinoids or phytocannabinoids)
Chemotypes
chemically different members of the same species
1. THC-Dominant
2. THC:CBD balanced
3. CBD-Dominant
4. CBG-Dominant
5. No Cannabinoids
What is the heavy phytocannabinoid hitter?
THC
THC
tetrahydrocannabinol
What do the terms "marijuana" and "hemp" reflect?
The phytocannabinoid profile and determine legal restrictions of use
Marijuana
Concentration in dried female flowers is as high as 20-30%
-Higher phytocannabinoid concentration
Hemp
Grown for fibrous properties
-Concentration = >1%
-no psychotropic effects
CBD
cannabidiol
Reason for high concentration in marijuana
have non-functional copies of genes encoding CBDA synthase so they make an excess of THCA
Reason for low concentration in hemp
have an intact copy of CBDA but don't have a functional THCA synthase, so they make more CBDA instead
Effects of cannabis
Modulate the activity of the body's endogenous cannabinoid system (ECS)
-Regulates appetite, mood, arousal, motor control, inflammation, and pain
Origin of cannabis
Early human use of cannabis as fiber 8,000 years ago in the Neolithic
When was the hemp-type introduced?
1500s
Therapeutic use of cannabis
-Chronis pain relief
-spasticity in multiple sclerosis
-opioid sparing
-seizures
-HIV/AIDS
-Neuropathic pain relief
Negative Impacts of cannabis
-impaired judgement
-reduced cognitive function
-enhanced anxiety
-fatigue
-negative cardiovascular effects
-both short and long term impacts
What is sake?
Japanese rice wine
Yoshida Brewery
144-year-old family-owned small brewery in northern Japan
process to make sake
1. rice is polished
2. rinse and soak until it has absorbed proper amount of water
3. Fermentation: Rice+water+yeast
Where is Mescaline native to?
Mexico and southwestern US
What are the 3 species of cacti discussed?
1. Peruvian Torch
2. Bolivian Torch
3. Rose Cactus
Mescaline is an __________.
Alkaloid, psychoactive compound
Where is Mescaline found?
Naturally found in Cacti
-also chemically synthesized versions
What were the earliest known uses of Mescaline?
-Psychotropic effects
-Medicinal purposes
-religious rituals
Indigenous uses of mescaline?
Physical Illnesses:
-snakebites
-burns
-wounds
-rheumatism
-toothache
-fever
1887: What effects did John Briggs describe from peyote ingestion?
-Heart Racing
-Breathing difficulty
Peyote
A cactus that produces the hallucinogen mescaline.
Other peyote alkaloids
Thought to enhance effects of mescaline:
Pellotine
Hordenine
Anhalonine
Absorption of Mescaline
Rapidly absorbed by gastrointestinal tract when consumed
Agonist
Mescaline is a serotonin receptor
-a molecule that increases a neurotransmitter's action
Effects of mescaline
Increases prosocial behavior, euphoria, hallucinations, improvements in well-being and mental health conditions
Mescaline increases __________ receptors
Happiness