GLP-1 RECEPTOR AGONISTS/ DPP-4 INHIBITORS/ INSULIN

Exenatide Bydureon, Byetta — GLP-1 receptor agonist

Exenatide SC/Function/Common Use SC — Mimics GLP-1; increases insulin activity, reduces glucagon activity, food intake, and gastric emptying — Type 2 diabetes; reduces blood glucose, cardiovascular event risks, and promotes weight loss

Exenatide Adverse Drug Reactions/Special Considerations Thyroid C-cell tumors (rats); pancreatitis — Nausea, vomiting, diarrhea, headache — Refrigerate unopened pens; in-use pens stable at room temperature for 30 days

Liraglutide Victoza, Saxenda — GLP-1 receptor agonist

Liraglutide SC/Function/Common Use SC — Mimics GLP-1; increases insulin activity, reduces glucagon activity, food intake, and gastric emptying — Type 2 diabetes; reduces blood glucose, cardiovascular event risks, and promotes weight loss

Liraglutide Adverse Drug Reactions/Special Considerations Thyroid C-cell tumors (rats); pancreatitis — Nausea, vomiting, diarrhea, headache — Refrigerate unopened pens; in-use pens stable at room temperature for 30 days

Linagliptin Tradjenta — DPP-4 inhibitor

Linagliptin PO/Function/Common Use PO — Reduces breakdown of GLP-1 and GIP — Type 2 diabetes

Linagliptin Adverse Drug Reactions/Special Considerations Worsening heart failure; pancreatitis — Joint pain, headache — Increased risk of low blood glucose when used with insulin

Saxagliptin Onglyza — DPP-4 inhibitor

Saxagliptin PO/Function/Common Use PO — Reduces breakdown of GLP-1 and GIP — Type 2 diabetes

Saxagliptin Adverse Drug Reactions/Special Considerations Worsening heart failure; pancreatitis — Joint pain, headache — Increased risk of low blood glucose when used with insulin

Sitagliptin Januvia — DPP-4 inhibitor

Sitagliptin PO/Function/Common Use PO — Reduces breakdown of GLP-1 and GIP — Type 2 diabetes

Sitagliptin Adverse Drug Reactions/Special Considerations Worsening heart failure; pancreatitis — Joint pain, headache — Increased risk of low blood glucose when used with insulin

Insulin aspart Novolog, Fiasp — Rapid-acting insulin

Insulin aspart SC/Function/Common Use SC — Mimics insulin from the body to reduce blood glucose — Type 1 and type 2 diabetes

Insulin aspart Adverse Drug Reactions/Special Considerations Hypoglycemia (low blood glucose) — Injection site reaction, weight gain — Increased risk of low blood glucose when used with other diabetes agents

Insulin lispro Humalog, Admelog — Rapid-acting insulin

Insulin lispro SC/Function/Common Use SC — Mimics insulin from the body to reduce blood glucose — Type 1 and type 2 diabetes

Insulin lispro Adverse Drug Reactions/Special Considerations Hypoglycemia (low blood glucose) — Injection site reaction, weight gain — Increased risk of low blood glucose when used with other diabetes agents

Insulin, regular human Novolin R, Humulin R — Rapid-acting insulin

Insulin, regular human SC/Function/Common Use SC — Mimics insulin from the body to reduce blood glucose — Type 1 and type 2 diabetes

Insulin, regular human Adverse Drug Reactions/Special Considerations Hypoglycemia (low blood glucose) — Injection site reaction, weight gain — Increased risk of low blood glucose when used with other diabetes agents

Insulin detemir Levemir — Long-acting insulin

Insulin detemir SC/Function/Common Use SC — Mimics insulin from the body to reduce blood glucose — Type 1 and type 2 diabetes

Insulin detemir Adverse Drug Reactions/Special Considerations Hypoglycemia (low blood glucose) — Injection site reaction, weight gain — Increased risk of low blood glucose when used with other diabetes agents

Insulin glargine Lantus, Basaglar — Long-acting insulin

Insulin glargine SC/Function/Common Use SC — Mimics insulin from the body to reduce blood glucose — Type 1 and type 2 diabetes

Insulin glargine Adverse Drug Reactions/Special Considerations Hypoglycemia (low blood glucose) — Injection site reaction, weight gain — Increased risk of low blood glucose when used with other diabetes agents