Antibiotics- nucleic acid inhibitors-folate antagonists

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8 Terms

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Sulfonamides

 Sulfamethoxazole/trimethoprim (+ cotrimoxazole)

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Sulfamethoxazole: inhibits

dihydropteroate synthase

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dihydropteroate synthase

 PABA → Dihydropteroic acid

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Trimethoprim: inhibits

dihydrofolate reductase

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dihydrofolate reductase

Dihydrofolic acid → Tetrahydrofolic acid

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Synergistic actions

occur via: Cotrimoxazole

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What pathway is inhibited by Cotrimoxazole

  • tetrahydrofolic acid (THF) pathway 

    • THF = critical precursor for thymidine + is essential for bacterial DNA synth 

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Cotrimoxazole uses

  1. UTI, uncomplicated pyelonephritis, + mild acute prostatitis

  2. UTIs and respiratory tract infections

  3. Salmonella infections