Mucosal epithelial cells and NOD
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8 Terms
What does NOD stand for?
NOD stands for a family of intracellular proteins that bind bacterial cell wall components.
Where are NOD1 and NOD2 present?
NOD1 and NOD2 are present in mucosal epithelial cells.
What happens when NOD1 and NOD2 bind bacterial cell wall components?
Binding activates a signaling cascade.
What is the first step in the signaling cascade after NOD1 and NOD2 binding?
The activation of protein kinase RIP2/RICK.
What happens after the activation of RIP2/RICK?
RIP2/RICK phosphorylates the TAK1 protein kinase.
What does TAK1 protein kinase activate?
TAK1 activates the IKK complex.
What is the result of IKK complex activation?
The IKK complex targets the inhibitory IκB for destruction.
What happens after the destruction of IκB?
Free NFκB is transported to the nucleus.
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