Exam I Review Problems

Which curve represents the release profile of loratadine from Claritin-D®?

a) Curve A

b) Curve B

c) Curve C

d) Curve D

e) Curve E

a) Curve A

Which curve represents the release profile of tramadol HCl from ConZip®CIV?

a) Curve A

b) Curve B

c) Curve C

d) Curve D

e) Curve E

b) Curve B

Drug release from a swellable monolithic matrix system depends on the ….

a) rate of swelling of the matrix

b) the dissolution rate of the drug in the matrix

c) diffusivity of the drug through the swollen gel matrix

d) water-solubility of the drug

e) all of the above

e) all of the above

What is the best way to prolong/sustain the effectiveness of a drug that is unstable in acidic conditions?

a) Sustained release with soluble matrix

b) Controlled release using insoluble matrix

c) Enteric-coated with slow-releasing core matrix

d) Osmotic (OROS) system

c) Enteric-coated with slow-releasing core matrix

A patient is worried about finding medication in their stool. Which of the following products might appear in the stool?

a) Concerta

b) Claritin D

c) Procardia XL

d) Klor-Con M15

e) Klor-Con

a) Concerta [OROS system w/ IR overcoat]

c) Procardia XL [OROS system]

e) Klor-Con [wax matrix insoluble tabs]

Properties of Claritin D

multilayer tablet w ER core

Properties of Klor-Con M15

KCl wax matrix insoluble microcapsules

Which of the following products is less likely to experience dose dumping?

a) Niaspan

b) Coreg

c) Procardia XL

d) Plendil

b) Coreg [coated microbeads system]

Characteristics of Niaspan

water-soluble matrix system

Characteristics of Plendil (Felodipine)

reservoir system

All the following medications can be administered subcutaneously, EXCEPT:

a) Invega Sustenna (paliperidone)

b) Imitrex STATdose system (sumatriptan)

c) Eligard kit® (leuprolide)

d) Tymlos® (abaloparatide)

e) Fragmin® (dalteparin)

a) Invega Sustenna (paliperidone) -- IM injection

Which of the following statements are important counseling points for this medication?

Rx

BUPROPION HCL ER (XL)

150 Tablets

Take 1 tablet by mouth daily for depression

a) Dissolve the medication on your tongue.

b) Do not crush or chew this medication.

c) This medication is designed to release the active ingredient slowly.

d) This medication will work quickly after taking it.

b) Do not crush or chew this medication

c) This medication is designed to release the active ingredient slowly.

Which of the following is true about Gliadel® (carmustine) wafers?

a) Gliadel wafers are implants that provide the drug locally.

b) Gliadel wafers improve efficacy and reduce adverse reactions of carmustine.

c) Gliadel wafers disintegrate upon administration for an immediate release of the drug.

d) Gliadel wafers deliver the drug directly into the surgical cavity after tumor resection.

e) Intravenous administration of carmustine provides a similar drug plasma profile as that of Gliadel wafers.

a) Gliadel wafers are implants that provide the drug locally

b) Gliadel wafers improve efficacy and reduce adverse reactions of carmustine

d) Gliadel wafers deliver the drug directly into the surgical cavity after tumor resection

A patient taking Omeprazole 20 mg Delayed-release Capsules comes to your pharmacy with a complex problem. Aging has led to a condition where the patient has nonmalignant cartilage-like webbing at the opening of the esophagus. Often the capsules become trapped in the webbing for hours, causing irritation and an uncomfortable feeling. The patient asks if there is a way to break open the capsule and take the medication with food. Omeprazole uses a non-sealed capsule. What advice should you give the patient?

a) Do not open the capsules, because the drug product is in a modified-release dosage form.

b) Open the capsules and sprinkle the beads into a soft food, such as applesauce, and advise the patient to swallow without chewing.

c) Open the capsules, grind up the beads into a fine powder, and take it with water.

d) Switch the patient to pantoprazole delayed released tablets.

b) Open the capsules and sprinkle the beads into a soft food, such as applesauce, and advise the patient to swallow without chewing

Bacterial endotoxin-free water can be prepared using which techniques?

a) Steam sterilization

b) Filtration using a 0.2-micron filter

c) Distillation

d) All of the above

c) Distillation

Choosing the correct syringe/needle size depends on …

a) route of administration

b) the viscosity of the formulation

c) the volume of medicament to be administered

d) patient’s factors such as obesity, muscle mass, and age

e) all of the above

e) all of the above

Which of the following products is NOT a targeted drug delivery?

a) Abraxane® (paclitaxel)

b) Doxil® (doxorubicin)

c) AmBisome® (amphotericin B)

c) AmBisome® (amphotericin B)

Which of the following is true about HEPA filters?

a) HEPA filters are used to remove particulates from large-volume parenterals

b) HEPA filters remove pyrogen for a solution

c) HEPA filters are used as a filter for sterilization by filtration

d) HEPA filters are used in the purification of air in aseptic workplaces, such as laminar flow hood

d) HEPA filters are used in the purification of air in aseptic workplaces, such as laminar flow hood

A hypertonic IV solution is required for an extremely edematous patient. Which of the following IV fluids is hypertonic?

a) D5 in 0.9% normal saline

b) Half normal saline (1/2NS)

c) 5% Dextrose in water (D5W)

d) 10% Mannitol

e) D5 in lactated ringers

a) D5 in 0.9% normal saline

d) 10% Mannitol

e) D5 in lactated ringers

Which of the following are the benefits of long-acting injectable antipsychotic medication?

a) Decreased risk of adverse metabolic effects

b) Reduced dose-related adverse effects

c) Improved adherence

d) Rapid relief of acute agitation

e) Reduced daily pill burden

b) Reduced dose-related adverse effects

c) Improved adherence

e) Reduced daily pill burden

What size filter is required to infuse the 30% Intralipid?

a) 0.10 micron

b) 0.22 micron

c) 1.2 micron

d) 5 micron

c) 1.2 micron

Penicillin G potassium is given to patients as an intermittent IV infusion (infuse over 15 to 30 minutes) or intramuscular (IM) by deep injection. While procaine suspension is only for deep IM injection. Which of the following is true?

a) Comparing equal doses, the procaine suspension will result in a much smaller AUC than that of an IV infusion.

b) Giving penicillin G potassium as an IV infusion will result in a higher Cmax as compared to the same IM dose.

c) Procaine suspension IM injections allow less frequent dosing.

d) The blood-drug profiles are similar for the two IM deep injections – Penicillin G potassium and penicillin G procaine.

b) Giving penicillin G potassium as an IV infusion will result in a higher Cmax as compared to the same IM dose.

c) Procaine suspension IM injections allow less frequent dosing.