antiplatelet characteristics

p2y12 inhibitor indication

coronary artery disease, ischemic stroke, peripheral artery disease

clopidogrel contraindication

active bleeding

clopidogrel bbw

may not be effective with reduced CYP2C19 activity

p2y12 inhibitor adr

c- minor bleeding

r- major bleeding (intracranial hemorrhage), thrombotic thrombocytopenic purpura

p2y12 and platelet aggregation inhibitor counsel

severe bleeding can occur but it is rare. it is common to bruise easily or take a little longer for minor cuts to stop bleeding. you should call your doctor if you have dark tarry stools (sign of digested blood), you cough up blood, or have a bleeding cut that wont stop. avoid taking NSAIDs

ticagrelor contraindication

active bleeding, history of intracranial hemorrhage

prasugrel contraindication

active bleeding, history of any TIA or stroke

clopidogrel/ prasugrel moa

irreversibly and directly inhibits ADP binding to receptor sites, inhibiting subsequent activation of the g2b3a complex

ticagrelor moa

reversibly and allosterically inhibits ADP binding to receptor sites. inhibiting subsequent activation of the g2b3a complex

platelet aggregation inhibitor indication

ischemic stroke or transient ischemic attack

platelet aggregation inhibitor contraindication

asthma

platelet aggregation inhibitor adr

c- headache, nausea, diarrhea

r- bleeding, bronchospasm, dress

dipyridamole moa

inhibits the uptake of adenosine into platelets, endothelial cells, and erythrocytes resulting in an increase in local concentrations of adenosine, which is a coronary vasodilator and a platelet aggregation inhibitor

aspirin moa

inhibits platelet aggregation by irreversible inhibition of platelet cyclooxygenase and thus inhibits the generation of thromboxane A2

dress

drug reaction with eosinophilia and system symptoms