Pharmaceutical Chemistry

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MIXTURE

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151 Terms

1

MIXTURE

a material that contains two or more components that do not chemically combine

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Decantation

Substances are separated based on the difference in specific gravity or density

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  • Decantation

  • Filtration

  • Distillation

  • Magnetic Separation

  • Centrifugation

  • Chromatography

METHODS OF SEPARATING COMPONENTS OF MIXTURES

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Filtration

Separation of solids from liquids by using a medium that only liquids can pass

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Magnetic Separation

Magnetically susceptible material is extracted from a mixture

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Centrifugation

Accelerate settling of particles by using force

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Chromatography

Separating components of mixtures makes use of differences in solvent affinity

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Atom

  • Basic unit of matter

  • Smallest particle of matter which enters a chemical combination

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PRINCIPAL UANTUM NUMBERS

represents the energy Level and the size of the atom

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n

Principal Quantum numbers symbol:

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AZIMUTHAL OR ANGULAR QUANTUM NUMBER

represents the shape of the orbital

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l

Azimuthal numbers symbol:

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MAGNETIC QUANTUM NUMBER

represents the orientation of the orbital in space

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ml

magnetic quantum numbers symbol:

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SPIN QUANTUM NUMBER

represents rotations of the electrons of the electrons

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ms

spin quantum numbers symbol:

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Ernest Rutherford

Who discovered proton?

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James Chadwick

Who discovered neutron?

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J.J Thomson

Who discovered electron?

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Hund’s Rule of Maximum Multiplicity

Electrons fill up orbitals singly first before pairing up

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Aufbau Building up Principle

Lower energy levels are filled up first before higher energy levels

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Heisenberg’s Uncertainty Principle

The exact position and momentum of an electron cannot be determined simultaneously

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FALSE

TRUE OR FALSE

No 2 electrons in an atom may have the same principal quantum number.

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TRUE

TRUE OR FALSE

An atom cannot have 2 electrons in the same energy level or orbital that have the same set of quantum numbers

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FALSE

TRUE OR FALSE

No more than 2 electrons may have the same set of quantum numbers

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FALSE

TRUE OR FALSE

Electrons in an atom may differ by, at most, one of four quantum numbers

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Antoine Lavosier

Discovered First TRUE PTE (33 elements)

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Johann Wolfgang Dobereiner

Arrange elements by 3’s (Dobereiner’s Triads)

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John Newlands

Arrange elements by 8’s (Octaves)

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Dmitri Mendeleev

Arranged elements by Atomic Weights

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Henry Moseley

  • Modern PTE

  • Arranged elements by Atomic Number

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Group IA

Alkali Metals

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Group IIA

Alkaline Metals

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Group IIIA

Icosagens

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Group IVA

Crystallogens

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Group VA

Pnictogens

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Group VIA

Chalcogens

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Group VIIA

Halogens/Salt Forming

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Group VIIIA or Group 0

Noble Gases/Inert Gas

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H, Li, Na, K, Rb, Cs, Fr

Group IA family:

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Be, Mg, Ca, Sr, Ba, Ra

Group IIA family:

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B, Al, Ga, In, Ti, Nh

Group IIIA family:

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C, Si, Ge, Sn, Pb, Fl

Group IVA family:

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N, P, As, Sb, Bi, Mt

Group VA family:

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O, S, Se, Te, Po, Lv

Group VIA family:

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F, Cl, Br, I, At, Ts

Group VIIA family:

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He, Ne, Ar, Kr, Xe, Rn

Group VIIIA family:

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Ts (Tennessine)

Atomic number 117 (Ununseptium)

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Nh (Nihonium)

Atomic number 113 (Ununtrium)

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Ms (Moscovium)

Atomic number 115 (Ununpentium)

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Og (Oganesson)

Atomic number 118 (Ununoctium)

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Group 1B

Coinage metals

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Group 2B

Volatile Metals

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Cr

Glucose tolerance factor

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Cu, Ag, Au (CoSiGo)

Group 1B elements:

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Zn, Cd, Hg (Zin Cad Mer)

Group 2B elements:

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Group 8B

Triads

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Fe, Co, Ni

Group 8B 1st triad:

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Ru, Rh, Pd

Group 8B 2nd triad:

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Os, Ir, Pt

Group 8B 3rd triad:

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Hydrogen

Lightest element

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Lithium

Lightest metal; melts above 100 °C

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Flourine

Most electronegative

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Cu, Zn, Be, Al, Sn, Pb

Amphoteric elements

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Metals (left side)

Forms basic anhydrides

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Nonmetals (right)

Forms acidic anhydrides

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Si, Ge, Po, Sb, As, Te, B

Metalloids

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At> I> Br> Cl> F

Most metallic among halogens Trend:

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F > Cl > Br> I > Ot

Most reactive among halogens Trend:

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Bridge Elements

  • diagonally related elements

  • Same properties, though belonging to different groups and periods

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Physical

Physical or Chemical change?

Dry Ice Formation

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Chemical

Physical or Chemical change?

Electrolysis of water

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Chemical

Physical or Chemical change?

KMnO4 + HCl

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Chemical

Physical or Chemical change?

Ammonia + H2O

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Active transport

Active transport or Passive Transport?

Uphill

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Active transport

Active transport or Passive Transport?

Energy is needed (ATP and Sunlight)

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Active transport

Active transport or Passive Transport?

Carrier mediated and saturable

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Active transport

Active transport or Passive Transport?

“against the concentration gradient”

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Passive transport

Active transport or Passive Transport?

downhill

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Passive transport

Active transport or Passive Transport?

energy is not needed

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Passive transport

Active transport or Passive Transport?

Carrier mediated: Facilitated Diffusion

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BULK TRANSPORT

  • transport of large amount of substance across plasma membrane by utilizing energy

  • solute and solvent are both transported across membranes

  • Examples: Phagocytosis (cell-eating) and Pinocytosis (cell-drinking)

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Phagocytosis

cell-eating

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Pinocytosis

cell-drinking

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OSMOSIS

Movement of solvent molecules (water) from an area of high solvent concentration to an area of low solvent concentration across a semi permeable membrane

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AMPHOTERIC

act either as acid or base

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AMORPHOUS

No definite form

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AMORPHOUS

Resins is an example of

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POLYMORPHIC

Solid chemical compounds that exist in more than one crystalline form

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POLYMORPHIC

Theobroma Oil or Cacao Butter is an example of

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Beta; 34*C

Polymorphic form of Theobroma Oil or Cacao Butter that is use as a suppository base

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ALLOTROPISM

Chemical elements exist in two or more different forms in the same physical state

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White Phosphorus

  • waxy, yellowish, white

  • toxic

  • from Phosphate containing rocks

  • garlic odor

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Red Phosphorus

heat white P at 573K (300°C)

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Black Phosphorus

heat white P at 473 K (200°C) and 1200-4000 atm pressure

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Violet Phosphorus

heat Red P at 823 K (550°C) for 1-2 weeks

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Enthalpy

a measure of the heat content of a chemical or physical system

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Entropy

Degree of total molecular randomness or disorderliness

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Latent Heat

energy released or absorbed by a body or a thermodynamic system during a constant-temperature process

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