lipid soluble hormones

what does lipid soluble mean

hydrophobic

what are lipid soluble hormones bound to in blood

carrier protien that protects it 

signal transduction that leads to gene activity results in what

increase or decrease in production of proteins coded by genes

goal of lipid soluble hormones

get hormone receptor complex into the nucleus from the cytoplasm so it can bind to DNA

what does hormone receptor complex bind to once in the nucleus

it binds to half sites on hormone response element on

HRE

hormone response element 

-has 2 half sites

-HR complex binds to 1 hald site

where is HRE found

found within promoter region of target gene

2 HR complexes in one HRE

forms a dimer (homodimer)

dimer does what

activates transcription followed by translation

translocate

HR complex and HR moving into nucleus

lipid soluble protien with receptor found in nucleus

binding protien is in cytoplasm

example. T4

T4 in cytoplasm 

when it binds to the the binding protein it converts into T3

receptor for thyroid in nucleus

its called TR for T3

T4 on HRE

TR doesn’t have to be on both half sites;

other receptor with TR on HR complex

RXR

-9-cis-retinoic acid receptor

2 molecule receptors on one HR complex

results in a heterodimer