Development of the Brain (Chapter 4)

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36 Terms

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Anecephaly
________:: does not fuse fully /completely in the anterior, cant have development of bone, muscle, skin in the brain.
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Meningocele
________:: dura mater inflates and pops out, grows as the brain produces more spinal fluid.
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immediate change
Fertilization of an egg- ________ to the cells, they begin dividing- the tissue divides itself into 3 layers.
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Alzheimers
________:: transition into total memory failure; buildup of beta- amyloid plaques (extracellular) and tau protein tangles (intracellular)
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GI
Endoderm:: ________ and res tracts, endothelial cells.
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→ keeps
Cerebral spinal fluid (which is only made in the outer boundaries of the ventricles) causes compression somewhere along the chamber- sensors further down tell the ventricles to produce more spinal fluid, but the fluid is blocked ________ making more and more and starts to crush neural tissue.
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Tangential migration
________:: parallel to the neural tube.
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Spina Bifida
________:: gap in the fusing of the vertebral column.
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MCI
________:: Mild Cognitive Impairment- prospective memory impairment and weak coding of new info.
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Myelomeningocele
________:: most severe; posterior region of neural tube, spinal cord fails to fully develop (like anecephaly); causes nerve damage and paralysis.
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ganglion
Dorsal root ________:: nerves that interface b /w body and spinal cord.
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Ectoderm
skin, nervous system
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Mesoderm
muscles and bones
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Endoderm
GI and res tracts, endothelial cells
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Neural plate will form
neural crest will fuse and set up foundation for the brain and spinal cord
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Forms central canal and becomes the neural tube
goes all the way thru entire length of cells (brain is at the anterior)
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Dorsal root ganglion
nerves that interface b/w body and spinal cord
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Forebrain
cortical regions, thalamus, hypothalamus
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Hindbrain
cerebellum, pons, medulla
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Anecephaly
does not fuse fully/completely in the anterior, cant have development of bone, muscle, skin in the brain
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Causes
folic acid (main cause), genetics (mutations), environment
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Spina Bifida
gap in the fusing of the vertebral column
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Meningocele
dura mater inflates and pops out, grows as the brain produces more spinal fluid
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Myelomeningocele
most severe; posterior region of neural tube, spinal cord fails to fully develop (like anecephaly); causes nerve damage and paralysis
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MOMS study (2003)
prenatal surgical closure of myelomeningocele
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Cerebral spinal fluid (which is only made in the outer boundaries of the ventricles) causes compression somewhere along the chamber
sensors further down tell the ventricles to produce more spinal fluid, but the fluid is blocked → keeps making more and more and starts to crush neural tissue
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Can treat by putting a shunt into the lateral ventricle
cerebral spinal fluid will drain thru the tube into the small intestine (almost always naturally rectifies)
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Tangential migration
parallel to the neural tube
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Somal translocation
neuron extends a little sticky arm and zooms to catch up with it
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Neuron differentiation
if the cell is a neuron, what kind of neuron
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Birth of synapses
neurons able to talk to other neurons; distinct processes for different areas of the brain; synaptic pruning after a process of fast development (think of farm to market roads example)
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Active cell death
healthy process cleaning up messes/unused pathways; cell death is based on competition; impaired in cancer and neurodegenerative diseases
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Body makes too many synapses to start with so they start to the fine tune their processes and rearrange; growth and complexity increase over time
essential fora health brain
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Abilities change across the lifespan
slower reaction time, larger vocab
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Balance b/w the body and the brain
both must work together to remain healthy
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Alzheimers
transition into total memory failure; buildup of beta-amyloid plaques (extracellular) and tau protein tangles (intracellular)