MHC heterozygosity: drawbacks
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Last updated 1:40 AM on 2/21/25
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4 Terms
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What are the drawbacks of increased MHC heterozygosity?
Increased variety of MHC molecules can lead to complications during infectious disease outbreaks and in organ and tissue transplantation.
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How will the new SARS-CoV-2 virus impact MHC alleles?
The new SARS-CoV-2 virus will drive selection of MHC alleles that are most capable of presenting viral peptides, which is referred to as directional selection.
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What is the trade-off of directional selection driven by SARS-CoV-2?
This shift in selective pressure comes at the expense of heterozygosity.
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