medchem mechanisms to remember
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34 Terms
Formation of carbene from diazonium compounds
The passerini reaction
The Ugi reaction
Synthesis of imines and imine derivatives you need to be aware of
The Hantzsch reaction
The Biginelli reaction
What are the conditions to install the Boc protecting group. How can it be uninstalled?
Halls reaction (phosphatase synthesis)
The Gewald reaction (to produce antibacterials)
How can you prep a polystyrene molecule for soldi phase organic synthesis?
What functionalised supports can you make from the chlorinated polystyrene resin?
Mechanism for a Swern type oxidation of a chlorinated polystyrene resin using DMSO
How to install/remove a wang linker from merrifields resin
Removed via TFA
How would you cleave a product from a silyl linker?
How can you load and cleave dihydropyran linkers? What is the mechanism?
How do you load/cleave acetal/ketal linkers
loading and cleaving of a silane linker which allows the traceless synthesis of aromatic compounds
Mechanism for protodesilylation of benzene ring
Loading and cleaving of substituent on selenide traceless linker
Mechanism for the traceless cleavage on selenide traceless linker
What is a safety catch linker - give an example of the loading and cleaving of such a thing
Safety catch linkers are inert to cleavage until activated. This prevents premature cleavage of the linker earlier in the synthesis.
What is a multifunctional linker
A linker which allows diversity to be introduced during the cleavage reaction.
How to synthesise a 1,4-benzodiazepine using a traceless linker:
How to install and remove Fmoc?
How to do a stille palladium catalysed carbon carbon cross coupling
What is a solid supported reagent and what are its uses
A reagent which is attached to an insoluble polymer support (duh) it requires no linking functionality, employs excess reagent to drive reaction equilibria to completion, helps work up and purification, avoid the release of toxic gases, it can be recycled, and more than one reagent may be used in a single pot reaction. Suitable for automation and allows convenient monitoring.
What are the simple and scavenging applications of solid supported reagents:
What is the catch and release application of solid supported reagents:
Wittig reaction b(convert aldehydes and ketones into alkenes
