Top 300 Quiz 5

CYCLOSPORINE

generic

Sandimmune

CYCLOSPORINE

Dosage Forms

Ampule

CYCLOSPORINE

Ampule

250 mg/5 mL

CYCLOSPORINE

Common FDA Label Indication, Dosing, and Titration

Heart, kidney, or liver transplant rejection

CYCLOSPORINE

MOA

prevents the activation of T-cell specific transcription factor → reduces the production of interleukin-2 and suppresses interferon-γ

CYCLOSPORINE

Box Warnings

Immunosuppression, bioavailability, psoriasis, hypertension/nephrotoxicity, experienced provider

CYCLOSPORINE

Contraindications

Hypersensitivity to polyoxyethylated castor oil

CYCLOSPORINE

Adverse Reactions

Gingival hyperplasia

hair growth

leg cramps

renal insufficiency

tremor

urinary tract infection, viral infection

Acute tubular necrosis

encephalopathy

sepsis

CYCLOSPORINE

Key Patient Counseling Points

Avoid alcohol, grapefruit, and grapefruit juice

Monitor

Avoid excessive exposure to UV light

HYDROCHLOROTHIAZIDE

Dosage Forms

Oral Capsule

Oral Tablet

HYDROCHLOROTHIAZIDE

Oral Tablet

12.5 mg, 25 mg, 50 mg

HYDROCHLOROTHIAZIDE

Oral Capsule

12.5 mg

HYDROCHLOROTHIAZIDE

Common FDA Label Indication, Dosing, and Titration

Edema

HTN

HYDROCHLOROTHIAZIDE

MOA

Thiazide Diuretic

HYDROCHLOROTHIAZIDE

Dose Adjustment Renal

yes

HYDROCHLOROTHIAZIDE

Contraindications

Hypersensitivity to sulfonamide

dofetilide therapy

anuric patients

HYDROCHLOROTHIAZIDE

Adverse Reactions

Hypotension, dizziness, headache

Cardiac arrhythmias

hepatitis

pancreatitis

SJS

HYDROCHLOROTHIAZIDE

Key Patient Counseling Points

May be taken with or without food

Take early in the day to avoid nocturia

Eat high-potassium foods during therapy

Avoid alcohol and NSAIDs

Calcium and vitamin D should be taken under medical supervision to avoid hypercalcemia

HYDROXYCHLOROQUINE

generic

Plaquenil, Sovuna

HYDROXYCHLOROQUINE

Dosage Forms

Oral Tablet

HYDROXYCHLOROQUINE

Oral Tablet

100 mg, 200 mg, 300 mg, 400 mg

HYDROXYCHLOROQUINE

Common FDA Label Indication, Dosing, and Titration

Lupus erythematosus

Malaria, suppression

Rheumatoid arthritis

HYDROXYCHLOROQUINE

MOA

Aminoquinoline

Unknown

HYDROXYCHLOROQUINE

Contraindications

retinal or visual field changes from prior hydroxychloroquine

children

HYDROXYCHLOROQUINE

Adverse Reactions

None known

Arrhythmias

cardiomyopathy

SJS

agranulocytosis

seizures

retinopathy

psychosis

HYDROXYCHLOROQUINE

Key Patient Counseling Points

If taking weekly, take on same day each week

Take with food or milk

GUAIFENESIN

generic

Mucinex

GUAIFENESIN

Dosage Forms

Oral Solution

Oral Syrup

Oral Liquid

Tablet

Tablet, Extended Release

Granule Packets

GUAIFENESIN

Oral Solution

100 mg/5 mL, 200 mg/mL

GUAIFENESIN

Oral Syrup

100 mg/5 mL

GUAIFENESIN

Oral Liquid

100 mg/5 mL

GUAIFENESIN

Tablet

200 mg, 400 mg

GUAIFENESIN

Tablet, Extended Release

600 mg, 1200 mg

GUAIFENESIN

Granule Packets

100 mg/packet

GUAIFENESIN

Common Self-Care Indications, Titration, and Dosing

Cough

GUAIFENESIN

MOA

thinning bronchial secretions and increasing sputum volume

GUAIFENESIN

Adverse Reactions

Nausea

vomiting

constipation

somnolence

risk of kidney stones

GUAIFENESIN

Key Patient Counseling Points

adequate rest and hydration

Tastes awful; do not chew or crush

Not for persistent cough or OTC use in children <2 y of age

ER formulation not for children <12 y of age

HYDROGEN PEROXIDE

generic

Peroxyl

HYDROGEN PEROXIDE

Dosage Forms

Solution External

Oral Gel

Oral Solution

HYDROGEN PEROXIDE

Solution External

3%

HYDROGEN PEROXIDE

Oral Gel

Oral Solution

1.5%

HYDROGEN PEROXIDE

Common Self-Care Indications, Titration, and Dosing

aphthous ulcers

Topical wound irrigation

HYDROGEN PEROXIDE

MOA

hydrogen peroxide → molecular oxygen

HYDROGEN PEROXIDE

Adverse Reactions

Skin bleaching

burns

fatal adverse effects if ingested

HYDROGEN PEROXIDE

Key Patient Counseling Points

When used topically, solution should be dried before covering area with bandage

Concentrated product (40%) should not be used clinically for any purpose

“swish and spit” technique for oral ulcers

oral ulcers should be counseled on good oral hygiene, avoidance of irritants (foods, etc), and if pain is present, on the use of topical analgesics

If oral ulcers persist for >7 d, seek medical attention

MICONAZOLE

generic

Desenex, Lotrimin AF

MICONAZOLE

Dosage Forms

Aerosol Spray, Powder, Cream, Ointment, Solution, Vaginal Cream, Vaginal Suppository

MICONAZOLE

Aerosol Spray, Powder, Cream, Ointment, Solution, Vaginal Cream

2%

MICONAZOLE

Vaginal Suppository

100 mg

200 mg

MICONAZOLE

Common Self-Care Indications, Titration, and Dosing

Skin fungal infections

Vulvovaginal candidiasis

MICONAZOLE

MOA

Inhibits biosynthesis of ergosterol

MICONAZOLE

Adverse Reactions

None known

Rash, hypersensitivity

MICONAZOLE

Key Patient Counseling Points

Wash and dry area before applying

For athlete’s foot, allow shoes to dry between wearing

Change socks several times daily to keep the foot dry

avoid skin-to-skin contact with infected area to prevent spread

Vaginal products are petrolatum based, which weakens condoms; alternative form of birth control

7 d or 3 d formulations may be more effective

Use nightly at bedtime; throw applicator away after use