Exam 3 Top 200 Drugs

Aripiprazole trade name

Abilify

Aripiprazole indication

Bipolar disorder, schizophrenia, depression, Tourette syndrome, autistic disorder

Aripiprazole drug class

second generation antipsychotic

Aripiprazole MOA

An atypical antipsychotic agent (quinolinone derivative). It exhibits partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at 5-HT2A receptors.

Aripiprazole Pharmacogenetics

CYP2D6 poor metabolizers should receive a 50% lower dose

Escitalopram trade name

lexapro

escitalopram indication

Depression, Generalized anxiety disorder

Off-label: OCD, Panic disorder, Hot flashes, Binge eating disorder, Premature ejaculation

escitalopram drug class

SSRI, Antidepressant

Escitalopram MOA

S-enantiomer of citalopram and is an antidepressant that is a selective and potent inhibitor of 5-HT reuptake. 

escitalopram pharmacogenetics

Increased risk of adverse reactions with CYP2C19 poor metabolizers

Pramipexole trade name

Mirapex

Pramipexole indication

Parkinson's disease, restless leg syndrome

Pramipexole drug class

dopamine agonist, antiparkinson

Pramipexole MOA

non-ergot-derived dopamine D2 agonist

pramipexole pharmacogenetics

none known

Quetiapine trade name

Seroquel (XR)

Quetiapine indication

Bipolar disorder, schizophrenia, major depressive disorder

Off-label: Delirium in the critically ill

Quetiapine drug class

Antipsychotic (Atypical)

Quetiapine MOA

An antagonist at multiple neurotransmitter receptors in the brain. It antagonizes serotonin 5-HT2, dopamine D1 and D2, histamine H1, and adrenergic α1 and α2 receptors.

Quetiapine Pharmacogenetics

none known

Ropinirole trade name

Requip® XL

Ropinirole indication

Parkinson's disease, Restless leg syndrome

Ropinirole drug class

Dopamine Agonist

Ropinirole MOA

nonergoline dopamine D2 agonist.

Ropinirole pharmacogenetics

none known

Sertraline trade name

Zoloft

Sertraline indication

Depression, OCD, panic disorder, PTSD, social phobia disorder, premenstrual dysphoric disorder

Sertraline drug class

SSRI, antidepressant

Sertraline MOA

selective and potent inhibitor of 5-HT reuptake

sertraline pharmacogenetics

none known