Ch. 15 - Adaptive Immune Response

Develop in bone marrow

B cells

Develop in thymus

T cells

B cells are part of ____________ immunity

Humoral

T cells are part of _____________ immunity

Cell-mediated

T cells become activated with help of _________ cells

dendritic

B cells become activated with help of _____ cells

T helper

T cells have a special _____ marker

CD

__________ system allow a place for immune cells (B & T cells) to come into contact with antigen

Lymphatic

Primary lymphoid organs

• bone marrow

• thymus

Secondary lymphoid organs

• lymph nodes

• spleen

• tonsils

• peyer’s patches

What level of organs are the only sites where the adaptive immune system can be activated?

secondary lymphoid organ

What does MALT stand for?

mucosa-associated lymphoid tissue

Peyer’s patches

important in mucosal immunity and antigen sampling

Antigen

antibody generator

Immunogenic

ability of antigen to elicit an immune response

If antigen is a __________ it induces a strong response

protein

If antigen is a _________ it induces a weak response

Lipid or nucleic acid

If antigen is ________ small it induces no response

small

Epitopes

Distinct regions of antigen

AKA antigenic determinants

Epitopes

Fab region

contains antigen binding site

Fc region

part that other self cells recognize and have receptors for

Variable region

accounts for specificity

Constant region

allows other components of immune system to recognize specific classes of antibodies

Name 6 protective outcomes of antigen binding

• opsonization

• neutralization

• antigen dependent cellular toxicity

• cross-linking

• complement system activation

• immobilization and prevention of adherence

What immune function occurs in primary lymphoid organs like the bone marrow and thymus?

Development and maturation of lymphocytes (B and T cells).

Which characteristic of an antigen determines its ability to elicit an immune response?

Immunogenicity

What are the two major types of adaptive immunity, distinguished by the primary immune cells involved?

Humoral immunity (B cells) and Cell-mediated immunity (T cells).

What is the overarching purpose of the variable region in an antibody?

To account for the antibody's specificity to a particular antigen.