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Which zoonotic disease causes sudden death in herbivores with dark, unclotted blood oozing from body orifices and forms spores that persist for decades in soil?
Anthrax
Which "rabbit fever" disease has an extremely low infectious dose and may be transmitted by ticks, deer flies, or handling rabbits?
Tularemia
Which disease caused by Yersinia pestis presents with painful buboes and can spread cat-to-human via respiratory droplets?
Plague
Which chronic granulomatous respiratory disease of cattle is controlled using the caudal fold skin test and pasteurization of milk?
Tuberculosis (Mycobacterium bovis)
Which viral respiratory disease is characterized by antigenic shift and drift and uses pigs as "mixing vessels"?
Influenza A
Which avian-associated disease is transmitted through inhalation of dried bird feces and causes green diarrhea in birds and atypical pneumonia in humans?
Psittacosis (Chlamydia psittaci)
Which disease caused by Coxiella burnetii is highly resistant in the environment and spreads through aerosolized birth fluids and contaminated dust?
Q Fever
Which rodent-borne virus causes a pulmonary syndrome with rapid pulmonary edema and high mortality in the southwestern U.S.?
Hantavirus
Which arenavirus infection associated with pet hamsters and mice can lead to meningitis or encephalitis in humans?
Lymphocytic choriomeningitis (LCMV)
Which opportunistic pathogen causes chronic pyogranulomatous pneumonia and abscesses in foals living in dusty barns?
Rhodococcosis (Rhodococcus equi)
Which fungal disease associated with pigeon droppings has a thick capsule and may cause nasal masses and CNS disease in cats?
Cryptococcosis
Which poultry disease causes neurologic signs and conjunctivitis in humans and is controlled by vaccination and depopulation?
Newcastle disease
Which coronavirus infection originated from bats and caused a global pandemic of severe lower respiratory disease beginning in 2019?
SARS-CoV-2 (COVID-19)
Which coronavirus disease is associated with camels and causes severe pneumonia in the Middle East?
MERS
Which infection develops within 12-24 hours after a cat bite and causes rapid cellulitis due to normal feline oral flora?
Pasteurellosis (Pasteurella multocida)
Which flea-associated disease of kittens causes regional lymphadenopathy after a scratch?
Cat scratch disease (Bartonella henselae)
Which dog oral commensal bacterium can cause septic shock and DIC after bites, especially in asplenic patients?
Capnocytophaga canimorsus infection
Which "fish-handler's disease" produces painful purple skin lesions after puncture wounds while handling fish or meat?
Erysipeloid (Erysipelothrix rhusiopathiae)
Which rodent-associated disease presents with fever, rash on palms and soles, and arthritis after a rat bite?
Rat bite fever
Which macaque-associated virus causes vesicles at the bite site followed by rapidly fatal encephalitis?
Herpes B virus
Which neurotoxin-mediated disease produces muscle rigidity, lockjaw, and a sawhorse stance after deep contaminated wounds?
Tetanus
Which viral disease is nearly 100% fatal once neurologic signs appear and is diagnosed post-mortem with direct fluorescent antibody testing?
Rabies
Which zoonosis requires a 10-day quarantine of a biting dog to monitor for disease progression?
Rabies
Which parasite causes serpiginous, pruritic "creeping eruption" lesions after walking barefoot on contaminated sand?
Hookworm (cutaneous larva migrans; Ancylostoma)
Which mite infestation causes intensely itchy but self-limiting dermatitis in humans after contact with infested animals?
Acariasis (mange/Sarcoptes)
Which fungal infection is the most common zoonosis in veterinary medicine and produces circular alopecic ring lesions?
Dermatophytosis (Ringworm)
Which bacterial skin disease of livestock called "rain rot" forms paintbrush-like scabs and railroad-track branching filaments?
Dermatophilosis (Dermatophilus congolensis)
Which multidrug-resistant staphylococcal infection is commonly hospital associated and spreads between pets and humans?
MRSA
Which "rose gardener's disease" produces nodular lesions tracking along lymphatics after cat scratches or thorn injuries?
Sporotrichosis
Which rhabdovirus infection of livestock produces oral vesicles that resemble foot-and-mouth disease and can infect humans with flu-like illness?
Vesicular stomatitis
Which parapoxvirus causes crusty nodular lesions on the hands of shepherds and goat farmers?
Contagious ecthyma (Orf)
Which orthopoxvirus infection presents with fever, lymphadenopathy, and pustular rash and is associated with African rodents?
Monkeypox
Which filovirus causes viral hemorrhagic fever with shock and high mortality following contact with blood or body fluids?
Ebola/Marburg
Which henipavirus disease associated with pig farms causes severe encephalitis outbreaks in Southeast Asia?
Nipah virus
Which henipavirus transmitted from bats to horses causes severe respiratory disease and encephalitis in Australia?
Hendra virus
Which disease known as Bang's disease causes abortion storms in livestock and undulant fever in humans consuming unpasteurized dairy?
Brucellosis
Which spirochete infection spread through rat urine or floodwater causes jaundice, renal failure, and hemorrhage (Weil's disease)?
Leptospirosis
Which pig-associated infection may cause meningitis and permanent deafness in exposed humans?
Streptococcosis (Streptococcus suis)
Which foodborne pathogen from poultry or reptiles is the leading cause of bacterial gastroenteritis hospitalizations?
Salmonellosis
Which curved "gull-wing" bacterium from raw chicken can lead to bloody diarrhea and Guillain-Barré syndrome?
Campylobacteriosis
Which Shiga-toxin producing bacterium from undercooked ground beef causes hemorrhagic colitis and hemolytic uremic syndrome without fever?
E. coli O157:H7 (EHEC/STEC infection)
Which silage-associated bacterium causes circling disease in ruminants and miscarriage or meningitis in pregnant women?
Listeriosis
Which pork-associated infection causes fever and pseudoappendicitis and can grow at refrigerator temperatures?
Yersiniosis
Which heat-resistant, vancomycin-resistant fecal bacterium is commonly associated with UTIs?
Enterococcus
Which halophilic marine bacterium from raw seafood may cause rapidly fatal wound infections or severe sepsis?
Vibriosis (Vibrio vulnificus/parahaemolyticus)
Which chlorine-resistant protozoan causes profuse watery diarrhea and is commonly spread in pools and daycares?
Cryptosporidiosis
Which "beaver fever" parasite from mountain streams causes chronic greasy diarrhea and malabsorption?
Giardiasis
Which parasite with cats as the definitive host poses serious risk to pregnant women and causes abortion storms in sheep and goats?
Toxoplasmosis (Toxoplasma gondii)
Which roundworm causes visceral and ocular larval migrans in children exposed to contaminated sandboxes?
Toxocariasis (visceral larval migrans)
Which pig roundworm causes "milk spots" in the liver but is not acquired by eating pork?
Ascaridiosis (Ascaris suum)
Which raccoon roundworm causes severe neural larval migrans and requires heat (not chemicals) for egg destruction?
Baylisascariasis
Which parasite from undercooked pork or bear meat causes muscle pain and periorbital edema due to encysted larvae?
Trichinellosis
Which flea-transmitted tapeworm causes "rice-like" proglottids and perianal pruritus in children and pets?
Dipylidium caninum infection
Which pork tapeworm can cause cysts in the human brain leading to seizures and is the most common preventable cause of epilepsy worldwide?
Taeniasis/Cysticercosis (Taenia solium)
Which dog-sheep cycle tapeworm produces large hydatid cysts in the liver or lungs of humans?
Echinococcosis
Which fecal-oral viral hepatitis is associated with contaminated water and travel to areas with poor sanitation?
Hepatitis A
Which pork-associated hepatitis virus is zoonotic and commonly linked to undercooked pork products?
Hepatitis E
Which prion disease of cattle resulted from contaminated meat-and-bone meal and can cause variant Creutzfeldt-Jakob disease in humans?
Bovine Spongiform Encephalopathy (BSE)
Which prion disease of deer and elk causes progressive weight loss and environmental persistence of infectious agents?
Chronic Wasting Disease (CWD)
Tick-borne disease causing Bull's-eye rash and shifting leg lameness?
Lyme disease
Rash on wrists/ankles with vasculitis and thrombocytopenia?
Rocky Mountain Spotted Fever
Pancytopenia with monocyte infection?
Ehrlichiosis
Neutrophil infection with thrombocytopenia via Ixodes ticks?
Anaplasmosis
Maltese cross RBC parasite causing hemolytic anemia?
Babesiosis
Tick-borne rabbit-associated ulceroglandular disease?
Tularemia
Most fatal equine encephalitis causing "sleeping sickness" in horses?
Eastern equine encephalitis (EEE)
Equine encephalitis where horses amplify transmission?
Venezuelan equine encephalitis (VEE)
Flavivirus from Culex mosquitoes causing bird deaths and equine neurologic disease?
West Nile virus
Pneumonia after assisting goat abortions?
Q Fever
Crusty hand lesions after handling lambs?
Contagious ecthyma (Orf)
Itchy migrating rash after beach sand exposure?
Hookworm (cutaneous larva migrans)
Lymphatic nodules after cat scratch in immunocompromised person?
Sporotrichosis
Progressive neurologic decline years after eating contaminated beef?
BSE (variant CJD)
Fever and lymphadenopathy after skinning rabbits?
Tularemia
Which disease is considered a Category A bioterrorism agent because its spores persist in soil for decades and can be weaponized?
Anthrax
Which zoonosis has three classic human forms: cutaneous (black eschar), inhalational, and gastrointestinal?
Anthrax
Which respiratory zoonosis is most associated with handling pigeons, parrots, or turkeys and inhaling dried fecal dust?
Psittacosis
Which disease should you suspect in a shepherd with fever and pneumonia after cleaning a dusty lambing barn with many abortions?
Q Fever
Which pathogen spreads long distances in windborne dust because it is extremely environmentally resistant?
Coxiella burnetii (Q Fever)
Which rodent-associated disease should not be cleaned by sweeping or vacuuming droppings due to aerosolization risk?
Hantavirus
Which disease is classically linked with deer mice in the southwestern United States?
Hantavirus
Which fungal disease often causes facial swelling and nasal masses in cats and has a thick capsule visible on cytology?
Cryptococcosis
Which disease of foals is associated with failure of passive transfer and dusty paddocks?
Rhodococcosis
Which poultry disease may cause green diarrhea, neurologic signs, and conjunctivitis in exposed humans?
Newcastle disease
Which cat-associated infection is so common that prophylactic antibiotics are often recommended after deep cat bites?
Pasteurellosis
Which infection is most associated with kittens rather than adult cats and causes lymph node swelling weeks after exposure?
Cat scratch disease
Which zoonotic infection is especially severe in asplenic or alcoholic patients after dog bites?
Capnocytophaga infection
Which occupation is most classically linked to erysipeloid infection: fishermen, butchers, or fish processors?
Erysipeloid (Erysipelothrix rhusiopathiae)
Which infection should be suspected when a lab worker exposed to macaques develops encephalitis with very high mortality?
Herpes B virus
Which disease is prevented in foals by disinfecting the umbilicus shortly after birth?
Tetanus
Which disease may present in humans with hydrophobia and aerophobia due to painful pharyngeal spasms?
Rabies
Which virus forms Negri bodies in neurons on histopathology?
Rabies
Which zoonosis is commonly spread by fomites like grooming tools and clippers and fluoresces under a Wood's lamp?
Dermatophytosis (Ringworm)
Which skin disease produces "paintbrush" crusts and thrives in wet, rainy conditions?
Dermatophilosis
Which livestock disease produces vesicles on the mouth, teats, and coronary bands and must be differentiated from foot-and-mouth disease?
Vesicular stomatitis
Which poxvirus infection of sheep and goats is commonly called "soremouth"?
Contagious ecthyma (Orf)
Which poxvirus infection is distinguished from smallpox by prominent lymphadenopathy?
Monkeypox
Which viral hemorrhagic fever is associated with cave bats and mining exposure?
Marburg virus disease
Which Brucella species is considered the most zoonotic and is associated with sheep and goats?
Brucella melitensis (Brucellosis)
Which disease is screened in dairy cattle herds using the milk ring test?
Brucellosis