Drug Ed Ch 7

Withdrawal from long-term use of sedative-hypnotic drugs is characterized by

A. aching, high blood pressure, drowsiness.

B. anxiety, impaired concentration, insomnia, convulsions.

C. rapid mood swings.

D. minor discomfort, but no serious symptoms.

B. anxiety, impaired concentration, insomnia, convulsions.

Animal self-administration experiments and studies of drug choice among humans indicate that

A. benzodiazepines have no dependence liability.

B. rats and people are very different in the drugs they choose to self-administer.

C. short-acting barbiturates are more likely to lead to dependence than any of the benzodiazepines.

D. all of the benzodiazepines have high dependence liability.

C. short-acting barbiturates are more likely to lead to dependence than any of the benzodiazepines.

Sedative-hypnotic agents bind to which receptors in the brain?

A. glutamate

B. GHB

C. serotonin

D. GABA

D. GABA

The four most widely sold benzodiazepines are all longer-acting drugs sold primarily as

A. anxiolytics.

B. analgesics.

C. hypnotics.

D. antidepressants.

A. anxiolytics.

Zolpidem (Ambien) is:

A. an older sleeping pill that is no longer marketed.

B. an intermediate-acting barbiturate.

C. not a benzodiazepine chemically, but it has similar effects.

D. a long-acting benzodiazepine.

C. not a benzodiazepine chemically, but it has similar effects.

When benzodiazepines bind to their receptor site, they

A. release barbiturates.

B. block acetylcholine receptors.

C. reduce the membrane electrical potential.

D. enhance the inhibitory effects of GABA.

D. enhance the inhibitory effects of GABA.

The "date-rape" drug Rohypnol (flunitrazepam)

A. is no longer manufactured legally.

B. is sold as a hypnotic agent (sleeping pill) in many countries other than the U.S.

C. was never marketed by any company because of its unusual impairment of memory.

D. is available by prescription in the U.S.

B. is sold as a hypnotic agent (sleeping pill) in many countries other than the U.S.

Librium (chlordiazepoxide) and Valium (diazepam) were the first widely sold

A. benzodiazepines.

B. barbiturates.

C. methaqualones.

D. sedatives.

A. benzodiazepines.

The major advantage of the benzodiazepines over the barbiturates seems to be the

A. lower cost.

B. greater effectiveness.

C. shorter duration of activity.

D. greater safety margin.

D. greater safety margin.

Two drugs that were introduced as being safer than the barbiturates, but in the long run proved to be not much safer, were

A. fluoxetine and paroxetine.

B. toluene and xylene.

C. meprobamate and methaqualone.

D. perphenazine and thiazine.

C. meprobamate and methaqualone.

Among the barbiturates, when prescribing a sleeping pill (hypnotic), physicians would usually choose a

A. higher dose of a short-acting drug.

B. lower dose of a long-acting drug.

C. higher dose of a long-acting drug.

D. lower dose of a short-acting drug.

A. higher dose of a short-acting drug.

How are barbiturates usually classified?

A. duration of action

B. price

C. chemical structure

D. strength of hypnotic effect

A. duration of action

What has kept paraldehyde from being widely used?

A. danger to the CNS

B. bad taste and odor

C. danger to the respiratory system

D. irritation to the gastric system

B. bad taste and odor

Which of these is NOT one of the early sedative-hypnotics used in medicine?

A. chloral hydrate

B. paraldehyde

C. butyrate

D. bromide salts

C. butyrate

The CNS depressants include various prescription drugs referred to as

A. GHBs.

B. sedative-hypnotics.

C. entheogens.

D. catecholamines.

B. sedative-hypnotics.