Top 200 Drug Interactions

PTCB

Warfarin + NSAIDs (Aspirin, Ibuprofen)

Increased risk of bleeding complications due to additive effects on coagulation.

ACE Inhibitors + Potassium Supplements

Risk of elevated potassium levels (hyperkalemia); requires monitoring of electrolyte balance.

Sildenafil + Nitroglycerin

Risk of a severe and sudden drop in blood pressure (hypotension).

Amiodarone + Warfarin

Potentiation of anticoagulant effects, increasing the risk of adverse bleeding events.

Statins + CYP3A4 Inhibitors (Clarithromycin)

Increased serum levels of the statin, elevating the risk of muscle related toxicity.

Levothyroxine + Calcium/Iron Supplements

Reduced absorption of the thyroid hormone, leading to decreased therapeutic efficacy.

Digoxin + Loop Diuretics (Furosemide)

Diuretic induced electrolyte imbalances can increase the risk of digoxin related toxicity.

SSRIs + Tramadol

Pharmacodynamic interaction increasing the risk of a serious neurological reaction (serotonin syndrome).

Ciprofloxacin + Antacids (Calcium, Magnesium)

Formation of insoluble complexes (chelation) that significantly reduce antibiotic absorption.

Spironolactone + ACE Inhibitors

Additive effects leading to potentially dangerous elevations in serum potassium.

Warfarin + Certain Antibiotics (Bactrim)

Alteration of vitamin K synthesis or metabolism, increasing anticoagulant activity.

Metformin + Iodinated Contrast Dye

Interaction that may affect renal function and increase the risk of metabolic complications.

Clopidogrel + Omeprazole

Inhibition of the enzyme necessary to activate the antiplatelet medication, reducing its effectiveness.

MAOIs + Sympathomimetics (Pseudoephedrine)

Risk of a severe hypertensive reaction due to excessive pressor activity.

Benzodiazepines + Opioids

Additive central nervous system depression, which can lead to severe respiratory impairment.

Lithium + NSAIDs

Reduced renal clearance of lithium, leading to increased risk of toxicity.

Calcium Channel Blockers + Beta Blockers

Additive effects on the heart's electrical system, potentially causing heart rate or rhythm issues.

Phenytoin + Warfarin

Complex metabolic interaction that can lead to unpredictable levels of both medications.

Grapefruit Juice + Certain Statins

Inhibition of intestinal metabolism, significantly increasing the concentration of the medication.

Allopurinol + Azathioprine

Interference with the metabolism of the immunosuppressant, increasing the risk of blood