B3 & 4s

Considerations when metal is present with C=O

can coordinate and distort Fehn-Alkin model

Potential effect of mCPBA on epoxidation close to alcohol

H bonds with another OH, if present, causing it to have the same formation (up or down) as OH

Houk’s model

The lowest energy conformation of a chiral alkene will have the H eclipsing the double bond (cis has 1, trans has more potential conformaers)

Reasons that stupid phosphorus, 2 benzenes bonded molecule is chiral

• limited movement around the biaryl C-C bond

• the ends of the benzenes face opposite directions

conformational diagram for transdeclin (2 cyclohexane-like things)

2 normal chairs next to each other

conformational diagram for cis declin

one normal chair, one down chair

potential reasons for cycle fragmentation happening

• lp on N goes into C-C sigma*

Beckmann Rearrangement clue

R-C=N-OH + H2SO4 or PCl5

What happens during a beckmann rearrangement

an APP group to the N ‘moves up’ to bond to the N

potential coupling in cyclohexanes

• W coupling (between 2 equatorial Hs 3 Cs apart, forms W shape)

  • 0-5 Hz

• ax|ax / eq|eq coupling (between 2 adjacent axial Hs)

  • 5-10Hz

• eq|ax (between adjacent equatorial and axial Hs)

  • 5-10 Hz

• geminal coupling (on the same C)

  • 10-15 Hz

how do electronegative atoms impact Fehn-Alkin model

they act big so need to be perpendicular

How does OsO4 react

• alkene attack 1 O

• Double bond pushed onto Os

• an O attacks the other side of the alkene syn to the previous attack

• H2O hydrolyses OsO4 thing to free the 2 bonded O’s