Unit 10: Perfusion D - Coagulation

Coagulation

Process of forming blood clots

Anticoagulation

Opposite of coagulation - prevention of clot formation

Hemostasis

Creates a balance of clotting in the body - creating clots when needed (For example, a patient gets injured) and preventing excessive clotting

Thrombus

A stationary clot (Stays in place!)

Embolism

A traveling clot (Air, fat, thromboembolism)

Thromboembolism

When a piece of the clot breaks off from its original place and travels through the blood stream until it gets stuck (This creates a major problem!) 

Who are the first responders to an injured blood vessel?

Platelets 

What are common coagulation disorders?

1. Thrombocytopenia

2. Hemophilia

3. Clotting factor deficiencies

Thrombocytopenia

Low platelets in the blood

True or False: A patient can clot too much

True

Labs for Coagulation Disorders

1. PT / INR 

2. aPTT

3. Liver function tests

4. Bleeding time

5. Serum levels of specific clotting factors 

True or False: Patients with liver failure don’t bleed a lot

False

What are the 2 anticoagulants?

Heparin and Enoxaparin

Enoxaparin is AKA?

Low Molecular Weight Heparin

What is the antiplatelet drug?

Eptifibatide

What is the thrmbolytic drug?

Alteplase

What are the Hemostatic drugs?

Aminocaproic Acid and Tranexamic Acid

True or False: Anticoagulants don’t dissolve clots

True

True or False: Thrombolytics do dissolve clots

True