MTAP2 Histo: Cell Death/Biopsy/Autopsy

apoptosis

generally triggered by normal, healthy process

necrosis

triggered by external factors

apoptosis

programmed cell death

necrosis

abnormal, harmful cell death

necrosis

unprogrammed cell death

coagulation necrosis

architecture of the dead tissues is preserved

coagulation necrosis

firm texture

coagulation necrosis

seen most often in the heart after an infarction, also kideys and spleen

infarct

localized area of a coagulative necrosis

liquefaction necrosis

transformation of the tissues into liquid viscous mass

liquefaction necrosis

seen in focal bacteria/fungal infections

liquefaction necrosis

pus

gangrenous necrosis

refers to massive death of tissue

coagulative

arterial occlusion

liquefactive

venous occlusion

coagulative

dry gangrene development

liquefactive

wet gangrene development

caseous necrosis

conversion of destroyed cells into granular, friable mass

granuloma

fragmented or lysed cells enclosed in an inflammatory border

caseous necrosis

granuloma in necrosis

fat necrosis

focal area of fat destruction

fat necrosis

acute pancreatitis

fat necrosis

release of pancreatic lipase

gaseous necrosis

combination of liquefactive and coagulative necrosis

fibrinoid necrosis

special form of vascular damage

fibrin

main reason for this fibrinoid necrosis

necrosis

cell size: enlarges

apoptosis

cell size: shrink

necrosis

plasma membrane: disrupted

apoptosis

plasma membrane: intact

biopsy

removal of cells or tissues suspicious for malignancy

membrane damage

hallmark of irreversible injury

excisional biopsy

type of biopsy - entire lump or suspicious area is removed

incisional or core biopsy

type of biopsy - only a sample of tissue is removed with preservation of the histological architecture of the tissue’s cell

incisional or core biopsy

type of biopsy - ample amount

fine need aspiration biopsy

type of biopsy - removed with a needle

punch biopsy

type of biopsy - circular blade

1-8 mm

size of circular blade

shave biopsy

type of biopsy - done with small scalpel or curved razor

curettage biopsy

type of biopsy - surface of tumor or on small epidermal lesions

curettage biopsy

type of biopsy - raspa patients

curette

surgical instrument that has a scoop, ring, or loop at the tip

necropsy

after death examination of the body

necropsy

to confirm cause of death