hallucinogens

hoffman 1943

first discovered hallucinogenic effect of lsd on bike trip

krebs and johansen 2013

lifetime use of lsd is not asociated with longterm mental health problems

baggot et al 2011

psilocybin and lsd users may experience flashbacks weeks after use

merck 1912

first synthesised MDMA

petronka et al 1988

more frequent mdma use leads to more negative side effects (paranoia, anxiety)

Schenk et al

rats will self administer MDMA but not LSD

pennington and reiffenstein 1986

mescaline does not inhibit raphe neuron firing, but is hallucinogenic, so raphe inhibition is not sufficient for hallucinogenesis

gonzales-maeso et al 2003

hallucinogen-evoked behaviour missing in 5HT2A KO mice

glennon et al 1984

strong correlation between 5HT2a binding and hallucinogenic properties

vollenweider et al 1998

subjective effects of psilocybin blocked by 5HT2a antagonists

kraehenmann et al 2017

dreamlike effects and cognitive bizarreness of LSD depend on 5HT2a receptor

Vollenweider and kometer 2010

proposed mechanism for hallucinogens is PFC overload due to glutamate increase of 5HT2a stimulation

capela et al 2009

mdma enters synaptic terminal through sert, promotes release of serotonin from vesicles and makes sert work in reverse, releasing serotonin into cleft

leichti et al 2001

most subjective effects of mdma blocked by SSRIs, moderate attenuation of effects by 5HT2a antagonists