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Purpose of fluid in the body
Transport medium
solvent
thermoregulation
digestion and elimination
lubrication
cellular metabolism/function
fluid dynamics
Intracellular
28L
Extracellular
14L
Intravascular
Interstitial
Lymph
Transcellular
How does fluid get in and out?
Eating + drinking
metabolism
perspiring
breathing
urine output
GI output
Most electrolytes enter the body in ___________, and most are excreted in ________
dietary intake, urine
Na+ & Cl-
aren’t stored so must be consumed regularly
Ka+ & Ca+
are stored in cells and bones
Cations & anions
dissolve in water
Na+ regulates…
Water balance, transmission of nerve impulses, Na-K pump
N for neurons
Cl- regulates…
With sodium maintains osmotic pressure
K+ regulates…
Electrical cardiac nerve conduction, cell metabolism-gluconeogenesis
K for kardiac
Ca+ regulates…
Nerve impulses, blood clotting, muscle contraction, needs vit D to be absorbed
PO4- regulates…
Helps form bones, cellular and nutrient metabolism, muscle, nerve and RBC function, CA levels and acid-base balance
Mg2+ regulates…
Relaxing muscle contractions, transmitting nerve impulses, regulates cardiac function, blood clotting, protein & DNA synthesis
HCO3 regulates…
essential part of carbonic acid-bicarbonate buffering system, regulated by kidneys
Homeostasis of fluid and electrolyte dependant on functioning of…
kidneys
heart
lungs
nervous system
adrenal pituitary and parathyroid glands
Renin
Produced in kidneys
Converts Angiotensinogen to angiotensinogen I
Angiotensin converting enzyme (ACE)
Produced in lungs
Converts angiotensin I to angiotensin II
Angiotensin II leads to…
Aldosterone
ADH
Systemic vasoconstriction
Aldosterone
Sodium/water retention in proximal convoluted tubules
ADH (pituitary)
Thirst/water intake (hypothalamus)
Reduced baroreflex to increase pressure
Most at risk of imbalances
Due to uncompensated gains or losses
Experiencing high intake
Experiencing high output
Unable to compensate for intake/output due to acute or chronic medical conditions
Hypovolemia
low circulating volume
Hypervolemia
Excess circulating volume
Comorbidities
GI
renal
neurological
cardiac diagnosis
Increased risk of of fluid + electrolyte imbalance
Age
Elderly - thirst response blunted and nephrons less able to conserve water
Increased likelihood of heart diseases, impaired RF, multiple meds
Younger people have more body fluid, more prone to dehydration (more demand for water)
Gender/body size
Fat cells have no H2O
Women have more fat = less body water
More obese, more fat = less water
Hospitalised
IV or PO therapies
NBM/GI disturbance
Diet
Anorexia, bulimia
malnourishment-low albumin
oedema acidosis
Lifestyle
Smoking, etc.
Exercise
Weight-bearing-CA balance
electrolyte loss
Inadequate intake
Nausea/anorexia
difficulty swallowing
lack of water access
NBM/intubation
Uncompensated loss
Diarrhoea
vomiting
polyuria
Haemorrhage
Burns
Symptoms of fluid volume deficit
dry oral cavity/furrowed tongue
thirst
cool pale skin, delayed capillary refill
weak, rapid pulse
decreased blood pressure
orthostatic hypertension
Orthostatic hypotension occured when a person’s _________ falls when suddenly standing up from a lying/sitting position
Defined as a fall in _________ blood pressure of at least 20mmHg or _________ blood pressure of at least 10mmHg when a person assumes a ________ position
Occurs by delayed __________ of ___________ blood vessels, which is normally required to maintain an adequate ________ when changing position to standing
As a result, blood pools in the ______ of the ________ for a longer period and less is returned to the ________ thereby leading to reduced ___________
Mild orthostatic hypotension common however prevalent among the ________ and those with known _________
Severe drops in BP can lead to _________ with possibility of injury
blood pressure
systolic, diastolic, standing
constriction, lower body, blood pressure
blood vessels, legs, heart, cardiac output
elderly, low BP
fainting
FVD interventions
Clinical assessment
Reduce losses
Increases intake
Reduce losses
Treat GI disturbances
Reduce diuretics
Stop bleeding
Increase intake
Oral rehydration
IV rehydration
Replacement fluids usually contain some electrolytes - why?
With fluid shift comes electrolyte shift
Crystalloid
Solute that can pass through a semipermeable membrane
Isotonic crystalloids
0.9% NACL
Ringers
Plasmalyte
Same osmolality as body fluids
Hypertonic crystalloids
5% dextrose
Higher osmolality
Hypotonic crystalloids
H20
0.45% NACL Ringers
Lower osmolality
Colloids
Albumin, FPP
Plasma protein fraction
Colloid substitutes
Dextran
Hetastarch
Blood transfusions
Packed RBCs
Whole blood
Causes of fluid volume excess
Uncompensated intake
Inadequate output
Uncompensated intake
Excessive IVF administration - includes blood transfusion
Excessive water consumption (polydipsia)
Inadequate output
Heart failure
Endocrine disturbances e.g. hyperaldosteronism
Liver failure
Renal impairment
Anuria (no urine output)/oliguria (scant urine output)
Symptoms of FVE
Neurological
Changes in LOC (level of consciousness)
confusion
headache
seizures
Respiratory
Pulmonary congestion
Cardiovascular
bounding pulse
increase BP and JVD
Presence of S3
Tachycardia
GI
Anorexia
Nausea
Oedema
Dependant pitting edema
Third space fluid
Shift of body fluids into potential spaces such as pleural, peritoneal, pericardial or joint cavities; the bowel; or the interstitial space
Fluid moves out of intravascular spaces (plasma) to any of these spaces
deficit in ECF volume occurs - fluid has not been lost but is trapped in another body space and unavailable for use
Fluid shifts may be related to…
a decrease in colloid osmotic pressure
an increase in capillary membrane permeability
a severe burn, a bowel obstruction or hypoalbuminaemia
FVE interventions
Clinical assessment
Restrict fluid/sodium intake
close fluid balance monitoring e.g. weight
± diuretics
dialysis
Nursing process for fluid balance
identify patients at risk of imbalances
determine that a specific imbalance is present and its severity, aetiology and characteristics
determine effectiveness of plan of care
Health history
risk factors for imbalances
comorbidities/chronic illnesses
abnormal fluid loss: burns, trauma, infection D&V, wounds
therapy that disrupts F&Es
Physical assessment
fluid balance in and out
daily weighs
Skin and mucous membranes
vital signs/haemodynamic monitoring
signs of FVE and FVD
Signs of electrolyte imbalance
Quality, colour and consistency of fluids coming out
Laboratory studies
Electrolytes
FBC
haemotocrit
albumin
osmolality
Urine pH and specific gravity
ABGs
24 urine (GFR)
Restoring electrolyte balance
treatment depends on aetiology (causal factors), severity, clinical signs, symptoms, rate of onset
can be difficult to treat (hyponatraemia and hyperkalaemia)
gradual approach preferred, unless condition life threatening
Reducing losses
Restoring electrolyte balance
restore normothermia
treat nausea and diarrhoea
return GI aspirates
reduce diuretics
Replacement
oral rehydration with electrolytes
oral electrolyte supplements
IV fluids with electrolytes
Reducing toxicity
Too much water
time
hydration/dilution
restrict intake
diuretics
glucose and insulin
calcium gluconate
dialysis
Hypokalemia
Major cation of ICF
body more sensitive to small changes in serum K+ than other electrolytes
K for kardiac!
Hyperkalemia
most common in patients with renal impairment or failure
life threatening
may require urgent intervention
Hyponatraemia FVD
Salt and water supplementation
Hyponatraemia FV balanced
fluid restriction
Hyponatraemia FVE
fluid restriction, ± diuretics, sodium supplementation
Hypernatraemia symptoms
dry mouth
low grade fever/flushinh
oedema, increased BP