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vWF disease
a platelet adhesion problem, mucosal/superficial bleeding
long bleeding time
normal PT
normal aPTT
normal MPV
Hemophilia A
factor 8 deficiency (intrinsic), deep bleeding
prolonged aPTT
normal PT
MPV normal
Vitamin K deficency
Extrinsic and Intrinsic problem, long bleeding
prolonged PT
normal aPTT
normal MPV
Rodenticide Toxicity
mimics vit K deficiency, long internal bleeding
prolonged PT
normal aPTT
normal MVP
Immune Mediated Thrombocytopenia (IMT)
mucosal bleeding, platelets destroyed, primary immune problem
normal PT
normal aPTT
low MPV
Disseminated Intravascular Coagulation (DIC)
Platelets clumping, sepsis
prolonged PT
prolonged aPTT
low MPV
intrinsic pathway
factor 12, 11, 9, 8
aPTT
normal is 12-17 sec
extrinsic pathway
factor 7 (shortest half-life), 3
PT
normal is 7-11 sec