Lecture 13- Carbohydrate metabolism IV-Glycogenlysis and Glycogenesis

what is glycogenlysis

break down glycogen for glucose- liver and muscles

first step of glycogenolysis

glycogen is broken down to glycose-1-phosphate and glycogen- by phosphorylase

what is the most afitavetd state of phosphorylase

relaxed activated form- most catalytic

what removes phosphate from glucose-1-phosphate?

protein phosphatase

how is is phosphorylase regulated

phosphorylation and calcium- make it fully active

what is glycogenesis

make glucagon from glucose

4 steps of glycogenesis

1. glucose phosprhoylation

2. glucose 1 phosphate formation

3. glucose activation

4. glucose addition to polymer backbone

enzymes used in glycogenesis

Glycogenin, glycogen synthase, glycogen branching enzyme

what activates of deactivates glycogenesis

• glucose 6 phosphate- activates

• phosphorylation- inactivates

• adrenaline- inactivates

some phosphorylase storage disease

V mcardle- muscle cramps

VI hens- liver- liver enlargement