Transcriptional specificity regulation

How does IκB degradation affect NF-κB activity

Allows selective activation of NF-κB homo- and heterodimers

Why does NF-κB form many dimers

A multigene family allows diverse dimers with distinct functions

How do NF-κB subunits differ in DNA binding

They have subtly different binding specificities

Do NF-κB subunits share target genes

Yes many target genes are shared

How does phosphorylation affect NF-κB activity

It controls interaction with co-activators and co-repressors

How is NF-κB linked to cancer

It regulates oncogene and tumour suppressor transcription

What enables NF-κB to access promoters

Chromatin remodelling and cooperative DNA binding