Pharmacology II: Estrogens and Androgens

Estradiol

Form of estrogen

(Steroid hormone that diffuses across the cell membrane and binds to estrogen receptors inside, stimulating synthesis of specific RNA/proteins)

Estrone

Form of estrogen

(Steroid hormone that diffuses across the cell membrane and binds to estrogen receptors inside, stimulating synthesis of specific RNA/proteins)

Estriol

Form of estrogen

(Steroid hormone that diffuses across the cell membrane and binds to estrogen receptors inside, stimulating synthesis of specific RNA/proteins)

Leuprolide

GnRH analog/agonist

(Pulse dose increases FSH/LH production, and continuous dose decreases FSH/LH production)

Gonadorelin

GnRH analog/agonist

(Pulse dose increases FSH/LH production, and continuous dose decreases FSH/LH production)

Nafarelin

GnRH analog/agonist

(Pulse dose increases FSH/LH production, and continuous dose decreases FSH/LH production)

Raloxifene

Selective estrogen receptor modulator (SERM)

(Competes with estrogen for binding in breast tissue as an antagonist and also decreases bone reabsorption/turnover)

Tamoxifen

Selective estrogen receptor modulator (SERM)

(Competes with estrogen for binding in breast tissue as an antagonist and acts as an agonist at uterus estrogen receptors)

Clomiphene

Selective estrogen receptor modulator (SERM)

(Acts as an estrogen receptor antagonist at ALL receptor types)

Drospirenone

Form of progestogen/progestin

(Produced in response to LH and promotes development of secretory endometrium)

Levonorgestrel

Form of progestogen/progestin

(Produced in response to LH and promotes development of secretory endometrium)

Medroxyprogesterone

Form of progestogen/progestin

(Produced in response to LH and promotes development of secretory endometrium)

Megestrol

Form of progestogen/progestin

(Produced in response to LH and promotes development of secretory endometrium)

Norelgestromin

Form of progestogen/progestin

(Produced in response to LH and promotes development of secretory endometrium)

Norethindrone

Form of progestogen/progestin

(Produced in response to LH and promotes development of secretory endometrium)

Progesterone

Form of progestogen/progestin

(Produced in response to LH and promotes development of secretory endometrium)

Mifepristone

Anti-progestin

(Progesterone antagonist)

Testosterone

Form of androgen

(Steroid hormone that diffuses across the cell membrane and binds to testosterone receptors inside, stimulating synthesis of specific RNA/proteins)

Bicalutamide

Anti-androgen

(Androgen receptor antagonist)

Flutamide

Anti-androgen

(Androgen receptor antagonist)

Nilutamide

Anti-androgen

(Androgen receptor antagonist)