DNA Packaging

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10 Terms

1
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What cancers is cisplatin used for?

Bladder

Lung

2
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What does cisplatin do?

Causes permanent structural distortion by binding tightly to the DNA —> tumor can’t divide anymore

3
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What type of strand does Chargaff rule apply to?

Double stranded DNA ONLY

4
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Chargaff Rule

A = T

G = C

The total amount of purines = the total amount of pyrimidines

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DNA denatures if

pH is altered (nucleotide bases ionize)

the DNA solution is heated

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What type of bonds are not broken by heat or pH change?

Covalent phosphodiester bonds

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The melting temperature

the temperature at which one half of the helical structure is lost

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Renaturation

Complimentary DNA strands can reform the double helix under appropriate conditions (lowering the temperature)

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What cancer is Daunorubicin used in?

Leukemia

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How does daunorubicin work?

Intercalates between the bases of DNA and interferes with replication

Does not bind directly to DNA